Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Dabigatran Etexilate Mesylate (CAS: 872728-81-9), also known as Pradaxa, is a synthetic oral direct thrombin inhibitor and dabigatran prodrug. It is a white to off-white crystalline powder, mainly used for preventing stroke, systemic embolism, DVT and PE, and also serves as a pharmaceutical reference material and research reagent.
Molecular Formula & Structure
Molecular Formula: C??H??N?O?S; Molecular Weight: Approximately 723.85 (salt form)
Physical Properties
- Appearance: White to off-white crystalline powder
- Melting Point: Approximately 120–125 °C (decomposes)
- Density: Approximately 1.32 g/cm3 (predicted)
- Solubility: Slightly soluble in water; soluble in methanol and DMSO; sparingly soluble in ethanol
- Stability: Stable at 2–8 °C (dry, dark); sensitive to humidity, temperature and light
Chemical Properties
- CAS Number: 872728-81-9; Chemical Type: Direct thrombin inhibitor, prodrug, pharmaceutical raw material
- Chemical Characteristics: Metabolized to active dabigatran in vivo, inhibiting thrombosis; contains benzimidazole, amidine and ester groups
- Applications: Clinical oral anticoagulant; pharmaceutical reference material; research reagent
- Toxicity: Moderate; main adverse reaction is bleeding; contraindicated in severe renal impairment and active bleeding.
Synthesis Method
- Raw Materials: Main intermediate, potassium carbonate, n-hexyl chloroformate, methanesulfonic acid and solvents.
- Synthesis Route: Multi-step synthesis including acylation, purification and mesylation, with refined purity up to 99.8%.
Storage & Safety
- Storage: Sealed, stored at 2–8 °C (dry, dark); avoid moisture, sunlight and high temperature.
- Safety: Wear protective equipment; avoid contact and ingestion; antidote for accidental ingestion is idarucizumab.
- Hazard: Non-flammable; decomposes when heated; avoid mixing with oxidants and acids.
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