Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
2-Amino-4-chlorobenzoic acid (CAS: 89-77-0), also known as 4-Chloroanthranilic acid, is a white to light beige crystalline powder. It is a valuable organic intermediate widely used in pharmaceutical, pesticide synthesis and biochemical research, especially serving as an inhibitor in quorum sensing research to combat antimicrobial resistance.
Molecular Formula & Structure
Molecular Formula: C?H?ClNO?; Molecular Weight: Approximately 171.58
Physical Properties
- Appearance: White to light beige or light yellow crystalline powder
- Melting Point: Approximately 231–235 °C (lit.); Boiling Point: Approximately 330 °C (rough estimate)
- Density: Approximately 1.3246 g/cm3 (rough estimate); Refractive index: 1.5560 (estimate)
- Solubility: Slightly soluble in water; almost transparent in 1 mol/L sodium hydroxide solution; sparingly soluble in common organic solvents
- Stability: Stable under normal temperature and pressure; hygroscopic; avoid strong oxidants and extreme conditions
Chemical Properties
- CAS Number: 89-77-0; EINECS Number: 201-938-5; Chemical Type: Aromatic carboxylic acid, organic intermediate, pharmaceutical intermediate
- Chemical Characteristics: Contains amino, chloro and carboxyl groups on the benzene ring; exhibits typical reactivity of aromatic amines and carboxylic acids; prone to acylation, esterification and substitution reactions.
- Applications: Key intermediate for pesticides and pharmaceuticals; research reagent for quorum sensing studies; used in organic synthesis and biochemical experiments.
- Toxicity: Irritating to skin, eyes and respiratory tract; labeled with GHS signal word "Warning"; harmful if ingested in large quantities; not for human or veterinary use.
Synthesis Method
- Raw Materials: 4-Chloro-2-nitrobenzoic acid (main raw material); catalyst (such as Pd/C for hydrogenation); reducing agent or acid/base for purification.
- Synthesis Route: Mainly via catalytic hydrogenation or chemical reduction of 4-chloro-2-nitrobenzoic acid to reduce the nitro group to amino group, followed by acidification, filtration and drying to obtain the target product.
Storage & Safety
- Storage: Sealed in airtight containers; store in a cool, dry and dark place below 30 °C; avoid moisture, sunlight and high temperature; keep away from incompatible substances.
- Safety: Operate in a well-ventilated environment; wear protective gloves, goggles and face protection; avoid skin, eye contact and inhalation of dust; wash thoroughly after handling.
- Hazard: Non-flammable under normal conditions; may emit irritating fumes when heated to decomposition; avoid mixing with strong oxidants and acids; rinse with plenty of water in case of contact.
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