Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
6-Aminopenicillanic acid (CAS: 551-16-6), abbreviated as 6-APA, is a white to pale yellow crystalline powder. As a core β-lactam compound and important pharmaceutical intermediate, it is mainly used for synthesizing semi-synthetic penicillins such as amoxicillin and ampicillin.
Molecular Formula & Structure
Molecular Formula: C?H??N?O?S; Molecular Weight: ~216.26; IUPAC Name: (2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; SMILES: CC1(C)S(C@@H)2(C@H)(N)C(=O)N2(C@H)1C(O)=O.
Physical & Chemical Properties
- Appearance: White to pale yellow crystalline powder, no visible impurities.
- Key Properties: Melting Point 198~209 °C (decomposition); Specific Rotation +270.0~+280.0 deg (C=1.2, 0.1mol/L HCl); Flash Point: Not applicable.
- Chemical Traits: Stable to acid, decomposes in alkali; slightly soluble in water, insoluble in ethanol, acetone and ethyl acetate; incompatible with oxidants.
- Toxicity: Low toxicity; GHS signal word "Warning"; may cause eye irritation and allergic reactions; slightly hazardous to water bodies.
Synthesis & Storage
- Synthesis: Mainly prepared by enzymatic hydrolysis of penicillin G or penicillin V using penicillin acylases; chemical cleavage method is also available.
- Storage: Sealed in airtight containers; stored at 2-8 °C in cool, dry and dark place; kept under inert gas; separate from oxidants; packed in 25kg plastic drums.
- Safety: Operate in well-ventilated environment; wear N95 mask, goggles and gloves; avoid inhalation and skin/eye contact; dispose in accordance with regulations.
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