Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Rhodanine-3-acetic acid (CAS: 5718-83-2), also known as 3-Carboxymethyl Rhodanine or (4-Oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acid, is an off-white to pale beige crystalline solid. As an important pharmaceutical intermediate, it is mainly used in the synthesis of the drug epalrestat and as an inhibitor for copper corrosion in acidic media.
Molecular Formula & Structure
Molecular Formula: C?H?NO?S?; Molecular Weight: ~191.23; IUPAC Name: (4-Oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acid; SMILES: S1CC(=O)N(CC(O)=O)C1=S; InChIKey: JGRMXPSUZIYDRR-UHFFFAOYSA-N.
Physical & Chemical Properties
- Appearance: Off-white to pale beige or pale yellow fine crystalline powder, no visible impurities.
- Key Properties: Melting Point 145~148 °C (lit.); Boiling Point ~375.4 °C (predicted); Density ~1.492 g/cm3 (estimate); Flash Point ~180.8 °C; Refractive Index ~1.5480 (estimate); pKa ~3.75±0.10 (predicted).
- Chemical Traits: Stable under dry and room temperature conditions; soluble in methanol (25 mg/mL, clear yellow), slightly soluble in water; incompatible with strong oxidants.
- Toxicity: Low toxicity; GHS signal word "Warning"; hazard code Xi; may cause skin, eye and respiratory irritation; WGK Germany 3; TSCA listed.
Synthesis & Storage
- Synthesis: Mainly prepared by microwave-assisted reaction—glycine, sodium hydroxide and carbon disulfide are reacted, then sodium chloroacetate is added for secondary reaction, followed by acidification, concentration and purification.
- Storage: Sealed in airtight containers; stored at room temperature in a dry and cool place; avoid moisture and direct sunlight; separate from oxidants; packed in 25kg plastic drums; HS CODE: 29341000.
- Safety: Operate in well-ventilated environment; wear protective gloves, goggles and face mask; avoid inhalation, skin and eye contact; follow safety statements S25, S26, S36, S39; dispose in accordance with regulations.
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