Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Physical Properties
- Appearance: White crystalline powder, odorless or with a faint characteristic amino acid-like scent.
- Melting Point: 187–190 °C (lit.), slight decomposition may occur at the upper limit.
- Boiling Point: 369.7 oC at 760 mmHg; decomposes before boiling under normal pressure in some conditions.
- Solubility: Slightly soluble in water (0.81 g/100 mL at 20 oC), slightly soluble in ethanol and DMSO, soluble in acids and polar organic solvents; solubility increases when heated.
- Density: Approximately 1.069 g/cm3 (calculated value).
- Optical Activity: Has optical activity, specific rotation α: -22 °C (c=5, EtOH) or -24.5 o (c=4, MeOH).
- Moisture Absorption: Slightly hygroscopic, easy to absorb moisture when exposed to air for a long time.
- Flash Point: 177.4 oC; refractive index: 1.458.
Chemical Properties
- Chemical Category: N-acylated amino acid, the N-acetyl derivative of L-leucine, belonging to branched-chain amino acid derivatives.
- Stability: Stable under ambient temperature and pressure; no known dangerous reactions if used and stored according to specifications; incompatible with strong oxidants and acidic chlorides, which may cause decomposition.
- Acid-Base Property: Weakly acidic, pKa value is 3.67 ± 0.10 (predicted); its aqueous solution is weakly acidic.
- Hydrolysis: Stable under normal storage conditions; can undergo hydrolysis reaction under extreme acid-base conditions to generate L-leucine and acetic acid.
- Photostability: Relatively stable to light, but long-term exposure to strong ultraviolet light may affect its stability.
- Reactivity: Suitable for C-H activation, solution phase peptide synthesis reactions; can be used as a catalyst in peptide synthesis; has enhanced metabolic stability and improved membrane permeability compared to parent amino acids.
Chemical Structure
Structural formula: $$\mathrm{C_8H_{15}NO_3}$$
（Complete structural diagram can be provided separately on request）
Applications
- Used in the research and treatment of vestibular-related imbalance, vertigo, cerebellar ataxia and nystagmus.
- Applied in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins.
- Used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for in vivo optical tumor imaging.
- Biomedical research reagent, suitable for pharmacological experiments, hormone mechanism studies and peptide synthesis reactions.
- Used as an optical resolution agent and auxiliary raw material in pharmaceutical and chemical synthesis.
Storage & Handling
- Storage Condition: Sealed, dry, cool and well-ventilated warehouse; away from direct sunlight, heat sources and moisture.
- Recommended Temperature: 2–8 ℃ for long-term storage (3 years); 20–25 ℃ for short-term (≤7 days) sealed storage; -20 ℃ for long-term storage of powder (3 years).
- Packaging: Aluminum foil bag vacuum packaging (10g/50g/100g) or chemical standard drum (1kg/5kg), moisture-proof and sealed to avoid contamination.
- Precautions: Avoid inhalation of dust and direct contact with skin or eyes; rinse with plenty of water immediately if contacted. Store separately from oxidants, acidic chlorides and other reactive chemicals.
Description
N-Acetyl-L-leucine (CAS: 1188-21-2) is an N-acylated derivative of the essential branched-chain amino acid L-leucine. It is a white crystalline powder with high purity (≥99.0% HPLC), slightly hygroscopic, and has good solubility in polar solvents. It has important applications in pharmaceutical research and clinical fields, especially in the research and treatment of vestibular disorders, as well as in peptide synthesis and biomedical imaging. Strict compliance with storage and handling requirements is necessary to ensure the quality and stability of the product.
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