Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Physical Properties
- Appearance: Colorless to light yellow clear liquid, odorless or with faint characteristic odor, no visible impurities.
- Melting Point: No definite melting point (liquid at room temperature, solidifies only at extremely low temperature).
- Boiling Point: 207.6 ± 23.0 °C at 760 mmHg; 85.5 °C under normal atmospheric pressure (partial boiling point data).
- Solubility: Insoluble in water, easily soluble in chloroform, n-heptane, ethanol, n-butanol and other organic solvents; slightly soluble in polar solvents.
- Density: 1.02 g/cm3 (at 25/4℃, lit.), 1.0±0.1 g/cm3 (calculated value).
- Optical Activity: No optical activity, belongs to racemic mixture with no chiral center.
- Moisture Absorption: Slightly moisture-sensitive, easy to absorb moisture when exposed to air for a long time, which may affect product stability.
- Flash Point: 91.6 ± 13.7 °C; refractive index: 1.4425-1.4445 (25 °C); vapor pressure: 0.2 ± 0.4 mmHg at 25 °C.
Chemical Properties
- Chemical Category: Halogenated ketone compound, alkyl chloride derivative, also known as 4-Chlorobutyl Methyl Ketone or 1-Chloro-5-hexanone.
- Stability: Stable under ambient temperature and pressure when stored in sealed and inert gas atmosphere; incompatible with strong oxidants, and may undergo decomposition reactions when in contact with them; sensitive to heat and air, easy to decompose when heated or exposed to air for a long time.
- Acid-Base Property: Neutral; its organic solution is neutral, and no obvious acid-base reaction occurs under normal conditions.
- Hydrolysis: Stable under neutral conditions; undergoes slow hydrolysis under strong acid or strong alkali conditions to generate corresponding alcohol and acid derivatives.
- Photostability: Relatively stable to light, but long-term exposure to strong ultraviolet light may cause slight discoloration and affect product purity.
- Reactivity: The carbonyl group in the molecular structure can undergo addition, reduction and condensation reactions; the chlorine atom can be substituted by nucleophiles, and can participate in substitution reactions with amines, alcohols and other compounds; it is an important intermediate for organic synthesis reactions.
Chemical Structure
Structural formula: $$\mathrm{C_6H_{11}ClO}$$ (Canonical SMILES: CC(=O)CCCCCl)
（Complete structural diagram can be provided separately on request）
Applications
- Pharmaceutical intermediate: An important intermediate for the synthesis of pentoxifylline, a drug for the treatment and prevention of cardiovascular and cerebrovascular diseases, which can improve red blood cell deformability and inhibit platelet aggregation.
- Chemical synthesis intermediate: Used in the synthesis of nylon, caprolactam, adipic acid and other products, and widely applied in the fields of synthetic fibers and rubber.
- Fine chemical synthesis: Used in the synthesis of spices, adhesives and other fine chemical products, and has broad application prospects in the fine chemical industry.
- Biomedical research reagent: Suitable for organic synthesis research, pharmacological experiment research and chemical reaction mechanism research.
- Industrial application: Used as a raw material in the production of organic intermediates and functional materials, and plays an important role in the chemical industry.
Storage & Handling
- Storage Condition: Store in a sealed container under inert gas atmosphere (such as nitrogen), placed in a cool, dry, dark and well-ventilated warehouse; away from direct sunlight, heat sources and moisture; avoid contact with air and incompatible substances.
- Recommended Temperature: Freezing storage (<0 ℃) for long-term storage; 20–25 ℃ for short-term (≤3 days) sealed storage under inert gas protection; avoid high temperature and rapid temperature changes.
- Packaging: Sealed glass bottle or plastic barrel packaging (100mL/500mL/1L) or chemical standard drum (20kg/200kg), filled with inert gas for protection, sealed and moisture-proof to avoid leakage and contact with air.
- Precautions: Avoid inhalation of vapor or mist; keep away from sources of ignition and no smoking; take measures to prevent electrostatic charge accumulation. Wear protective gloves, protective clothing, eye protection and face protection during operation. If it comes into contact with eyes, rinse cautiously with water for several minutes and remove contact lenses if present. In case of fire, use appropriate fire extinguishing agents for extinction. Waste disposal shall be carried out in accordance with industrial waste regulations; store separately from oxidants and other reactive chemicals.
Description
6-Chloro-2-hexanone (CAS: 10226-30-9) is a halogenated ketone organic compound with the chemical formula C?H??ClO and a molecular weight of 134.60. It is a colorless to light yellow clear liquid with a purity of ≥97.0% (GC), slightly moisture-sensitive and heat-sensitive. As an important organic synthesis intermediate, it has wide applications in pharmaceutical, chemical, fine chemical and other fields, especially in the synthesis of cardiovascular and cerebrovascular drugs and synthetic fibers. Strict compliance with storage and handling requirements (inert gas protection, sealed freezing storage) is necessary to ensure the quality and stability of the product, and avoid decomposition caused by contact with air, heat and moisture.
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