Physical Properties

• Appearance: White to off-white solid, odorless, no visible impurities, soluble in water to form clear solution.
• Melting Point: 149-155 °C (lit.), slight decomposition at upper limit.
• Boiling Point: Decomposes before boiling under normal atmospheric pressure, no definite boiling point.
• Solubility: Soluble in water (100mg/mL at 25℃), slightly soluble in DMSO (50mg/mL at 25℃); solubility decreases at low temperature.
• Density: Approximately 1.32 g/cm3 (calculated value, solid state at 25 °C).
• Optical Activity: Has optical activity, specific rotation (α)22/D -14°, c=10 in H?O (R-configuration).
• Moisture Absorption: Hygroscopic, easy to absorb moisture when exposed to air for a long time, may cause agglomeration.
• Flash Point: ≥110 °C; aqueous solution is clear, no visible impurities.

Chemical Properties

• Chemical Category: Hydroxy acid sodium salt, chiral compound, endogenous metabolite, also known as Sodium (R)-3-Hydroxybutyrate, D-BHB Na.
• Stability: Stable under ambient temperature/pressure (sealed); stable in inert gas atmosphere; hygroscopic, easy to absorb moisture and agglomerate.
• Acid-Base Property: Weakly alkaline; its aqueous solution is weakly alkaline, compatible with neutral and weakly alkaline substances.
• Hydrolysis: Stable under normal storage conditions; no obvious hydrolysis, stable in water solution for a short time.
• Photostability: Relatively stable to light, long-term exposure to strong ultraviolet light will not cause obvious discoloration or decomposition.
• Reactivity: Can act as a nutritional source and precursor of vitamins, antibiotics and pheromones; can react with crown ethers to form supramolecular complexes; participates in biological metabolic reactions.

Chemical Structure

Applications

• Biomedical research: Used as a research reagent in molecular biology, cell biology and pharmacology, for the research of metabolic mechanisms.
• Pharmaceutical industry: Intermediate for the synthesis of drugs, and used in the research of related drug development.
• Chemical synthesis: Used in the preparation of (R)-3-hydroxybutyric acid oligomers by catalyzing the regioselective ring-opening polymerization of (S)-butyrolactone.
• Cosmetics industry: Used as a skin conditioner, humectant and plasticizer, with anti-sebum effect.
• Research: Reagent for chiral compound research, metabolic mechanism research and organic synthesis reaction research.

Storage & Handling

• Storage: Sealed container, cool/dry/dark/ventilated; away from sunlight, heat, moisture and incompatible substances.
• Temperature: 2–8 °C (long-term, sealed); avoid high temperature and rapid temperature changes; shelf life 12 months.
• Packaging: Aluminum foil bag vacuum packaging (500mg/1g/5g) or sealed plastic barrel (25kg), moisture-proof and sealed.
• Precautions: Avoid inhalation of dust and direct contact with skin and eyes; wear experimental clothes and disposable gloves during operation; rinse with plenty of water immediately if contacted; dispose of waste properly.

Description