Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Physical Properties
- Appearance: White to off-white powder or crystal, odorless, uniform in particle size, no visible impurities.
- Melting Point: 186 °C (lit.), slight decomposition at melting point.
- Boiling Point: Approximately 389.3 °C (rough estimate), decomposes before boiling under normal atmospheric pressure.
- Solubility: Slightly soluble in water; soluble in chloroform, dichloromethane, ethyl acetate, DMSO and acetone; soluble in 1mol/L NaOH solution.
- Density: Approximately 1.186 g/cm3 (rough estimate, solid state at 25 °C).
- Optical Activity: Has optical activity, specific rotation (α)20/D +24.0～+30.0° (c=1, ethanol) or +25.8°～+27.0° (c=2, 1mol/L NaOH).
- Moisture Absorption: Slightly moisture-sensitive, moisture content not more than 0.3% under normal storage conditions.
- Flash Point: ≥110 °C; refractive index n20/D 1.645 (estimate); acidity coefficient (pKa): 3.65±0.10 (Predicted).
Chemical Properties
- Chemical Category: Amino acid derivative, acetylated amino acid, also known as Ac-Trp-OH, N-acetyl-L-tryptophan.
- Stability: Stable under ambient temperature and pressure (sealed); stable in inert gas atmosphere; incompatible with strong oxidants; sensitive to light and air, easy to deteriorate when exposed for a long time.
- Acid-Base Property: Weakly acidic; pKa value about 3.65, showing weak acidity in aqueous solution.
- Hydrolysis: Stable under normal storage conditions; can be hydrolyzed under strong acid or strong alkali conditions to generate L-tryptophan and acetic acid.
- Photostability: Sensitive to light, long-term exposure to strong ultraviolet light may cause slight discoloration and affect product purity.
- Reactivity: Can participate in peptide synthesis reactions as a protective amino acid; has skin protecting and conditioning effects; can form complexes with metal ions; non-flammable and non-explosive under normal conditions.
Chemical Structure
Structural formula: $$\mathrm{C_{13}H_{14}N_2O_3}$$ (Canonical SMILES: CC(=O)N(C@@H)(Cc1c(nH)c2ccccc12)C(O)=O)
（Complete structural diagram available on request）
Applications
- Pharmaceutical industry: Important intermediate for peptide synthesis and drug development, used in the synthesis of various peptides and pharmaceutical products.
- Cosmetics industry: Used as skin conditioner and skin protectant, applied in skin care products to improve skin texture and moisture retention.
- Chemical synthesis: Used as a protective amino acid in organic synthesis, widely used in the preparation of peptides, proteins and other bioactive substances.
- Laboratory research: Used as a research reagent in biochemistry, molecular biology and peptide synthesis research.
- Fine chemical field: Used as a raw material for the production of fine chemicals, food additives and feed additives.
Storage & Handling
- Storage: Store in a sealed container, placed in a cool, dry, dark and well-ventilated warehouse; away from sunlight, heat, air and strong oxidants.
- Temperature: Room temperature (≤15 °C, cool and dark place recommended) for long-term storage; avoid high temperature and rapid temperature changes; shelf life 12 months under proper storage conditions.
- Packaging: Sealed glass bottle (1g/25g) or aluminum foil bag vacuum packaging, moisture-proof and light-proof, sealed to avoid contact with air.
- Precautions: Avoid inhalation of dust and direct contact with skin and eyes; wear protective gloves, protective clothing and goggles during operation; rinse with plenty of clean water immediately if contacted accidentally; dispose of waste in accordance with industrial waste regulations; store separately from strong oxidants.
Description
N-Acetyl-L-tryptophan (CAS: 1218-34-4) is an acetylated amino acid derivative with the chemical formula C??H??N?O? and molecular weight 246.26. It is a white to off-white powder or crystal (purity ≥98.0% HPLC), slightly moisture-sensitive and has optical activity. As an important intermediate for peptide synthesis, it is widely used in pharmaceutical, cosmetics, chemical synthesis and laboratory research fields. It has skin protecting and conditioning effects and is suitable for use in skin care products. Store in a sealed, cool and dark place to ensure product stability and avoid deterioration caused by light and air.
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