Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
2,3,5,6-Tetramethyl-1,4-phenylenediamine (CAS: 3102-87-2), commonly known as Tetramethyl-p-phenylenediamine (TMPD), is an organic aromatic diamine compound with a benzene ring substituted by four methyl groups and two amino groups at the para positions. It appears as a pale yellow to light red crystalline powder or solid, with a characteristic amine-like odor. It has strong basicity and reducibility, and is prone to oxidation and discoloration when exposed to light or air, widely used in analytical chemistry, functional materials, and other fields.
Uses
Analytical Chemistry: It is mainly used as an oxidation-reduction indicator, electrochemical probe molecule, and free radical scavenger. Its reducibility and specific oxidation potential (+0.28V vs. SHE) make it suitable for redox titration and electrochemical analysis experiments, helping to determine the content of oxidants or reductants in samples.
Functional Materials Industry: Serves as a precursor for conductive polymers, an intermediate for dyes, and a component of photosensitive materials. It can also be used as an antioxidant and stabilizer, preventing spontaneous polymerization of peroxides in paints, coatings, and adhesives, and delaying the aging of materials such as rubber, polyesters, and fatty acid methyl esters.
Biological Detection: Used as a substrate for oxidases and a related reagent in mitochondrial research. It participates in the catalytic reaction of oxidases, generating detectable products, which is widely used in the detection of enzyme activity and related biological experiments.
Molecular Formula & Structure
- Molecular Formula: C??H??N?
- Molecular Weight: 164.247 g/mol
- IUPAC Name: 2,3,5,6-Tetramethylbenzene-1,4-diamine
- Synonyms: Tetramethyl-p-phenylenediamine; TMPD; 1,4-Diamino-2,3,5,6-tetramethylbenzene
Physical & Chemical Properties
- Appearance: Pale yellow to light red crystalline powder or solid; has a characteristic amine-like odor; no visible impurities.
- Melting Point: 150–155 °C (lit.).
- Boiling Point: 310.6 ± 37.0 °C at 760 mmHg (atmospheric pressure).
- Density: Approximately 1.0 ± 0.1 g/cm3 (at 25 °C).
- Refractive Index: 1.595 (at 20 °C).
- Flash Point: 167.8 ± 26.0 °C (closed cup).
- Vapor Pressure: 0.0 ± 0.7 mmHg at 25 °C.
- Solubility: Slightly soluble in water; freely soluble in organic solvents such as ethanol, ether, and acetone; slightly soluble in non-polar solvents.
- Stability: Stable under inert gas (nitrogen or argon) and dark conditions; prone to oxidation and discoloration when exposed to light, air, or high temperature; incompatible with strong oxidants; stable in neutral and alkaline environments, and may undergo protonation in acidic environments due to its basicity.
- Chemical Traits: It is an aromatic diamine compound with strong basicity and reducibility; the four methyl groups on the benzene ring enhance the electron density of the amino groups, making it easier to be oxidized; it has a conjugated structure, which is the basis for its application as an indicator and probe molecule.
- Toxicity: It has certain toxicity; may cause irritation to the skin, eyes, and respiratory tract; long-term or repeated contact may cause chronic damage; oral ingestion is harmful. It is contraindicated in individuals with known hypersensitivity to this product; avoid contact with skin, eyes, and mucous membranes during operation.
Synthesis & Storage
- Synthesis: Prepared by nitration reaction of p-toluidine, followed by reduction reaction to obtain the target product; after purification, drying, and crushing processes, the product quality meets industrial and laboratory standards, suitable for industrial production and laboratory use.
- Storage: Sealed in airtight containers filled with inert gas (nitrogen or argon); stored at 2–8 °C in a dark, dry place; avoid light, air, high temperature, and moisture; shelf life is about 18 months when stored properly; avoid contact with strong oxidants and acidic substances.
- Safety: Operate in a well-ventilated environment; wear protective gear (gloves, goggles, mask, protective clothing); avoid inhalation of dust or aerosols and skin/eye contact; wash hands thoroughly with soap and water after handling; if accidentally inhaled or in contact with eyes, rinse immediately with plenty of water and seek medical attention if irritation persists; dispose of waste in accordance with hazardous chemical waste regulations.
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