Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Mebeverine hydrochloride (CAS: 2753-45-9), also known as Mebeverine HCl, is an organic compound belonging to the class of musculotropic spasmolytics, which is a derivative of 3-phenethylamine of methoxybenzamine. It appears as a white to off-white crystalline powder, odorless or with a faint characteristic odor, and is soluble in dimethyl sulfoxide (DMSO) and water. As a selective gastrointestinal antispasmodic drug, it acts directly on gastrointestinal smooth muscle to relieve spasm without affecting normal gastrointestinal motility, and is widely used in the pharmaceutical industry for the treatment of digestive system disorders.
Uses
Pharmaceutical Industry (Main Use): Primarily used for the symptomatic treatment of spasmodic abdominal pain and intestinal dysfunction caused by irritable bowel syndrome (IBS); also applicable for the symptomatic treatment of intestinal spasm secondary to organic diseases. Its spasmolytic effect is 3-5 times that of papaverine, and it has no anticholinergic effect, making it suitable for patients with benign prostatic hyperplasia and glaucoma.
Clinical Application: Available in various dosage forms such as tablets, suspensions, and controlled-release preparations, convenient for different groups of patients (adults and children over 3 years old) to take. It is usually administered orally, with specific dosages adjusted according to age and dosage form, and is widely used in clinical practice for the relief of gastrointestinal spasm-related discomfort.
Research Application: Used as an analytical standard in pharmaceutical analysis and research; also used in in vitro studies related to gastrointestinal smooth muscle function, helping to explore the mechanism of gastrointestinal spasm and the development of related drugs.
Molecular Formula & Structure
- Molecular Formula: C??H??ClNO?
- Molecular Weight: 466.01 g/mol
- IUPAC Name: 4-(Ethyl(1-(4-methoxyphenyl)propan-2-yl)amino)butyl 3,4-dimethoxybenzoate hydrochloride
- Synonyms: Mebeverine HCl; Colofac; Duspatalin; 4-(Ethyl(p-methoxy-alpha-methylphenethyl)amino)butyl veratrate hydrochloride
- EINECS Number: 220-400-0
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder; odorless or with a faint characteristic odor; no visible impurities.
- Melting Point: 105–107 °C (lit.).
- Boiling Point: 543.8 °C at 760 mmHg (atmospheric pressure).
- Density: Not explicitly reported; stable under normal conditions.
- Flash Point: 282.7 °C (closed cup).
- Vapor Pressure: 6.92×10?12 mmHg at 25 °C.
- Solubility: Soluble in DMSO (≥ 155 mg/mL, 332.61 mM) and water; slightly soluble in ethanol; practically insoluble in non-polar organic solvents.
- Stability: Stable under normal temperature and dry conditions; sensitive to moisture and high temperature; should be stored in a cool and dark environment; incompatible with strong oxidants and strong acids.
- Chemical Traits: It is a hydrochloride salt of mebeverine, with a complex structure containing methoxy groups and amino groups; it has good water solubility, which is beneficial for oral absorption; it can inhibit α1 receptor activity and exert a spasmolytic effect on gastrointestinal smooth muscle.
- Toxicity: Low acute toxicity; LD50 (oral, rat) is 1540 mg/kg, LD50 (intravenous, rat) is 17.7 mg/kg; oral ingestion is harmful (GHS07, H302, R22). Adverse reactions are occasional, including headache, dizziness, abdominal distension, nausea, and skin allergies (rash, urticaria); contraindicated in patients allergic to mebeverine hydrochloride, those with intestinal obstruction, fecal impaction, colonic atony, and severe liver insufficiency.
Synthesis & Storage
- Synthesis: Prepared by esterification and amination reactions of veratric acid and related amino alcohol intermediates, followed by salification with hydrochloric acid, purification, drying, and crushing processes; the product quality meets USP, EP, and CP standards, suitable for industrial production of pharmaceutical preparations.
- Storage: Sealed in dry, airtight containers; stored at 2–8 °C in a dark, dry place; avoid moisture, high temperature, and direct sunlight; shelf life is about 2 years under proper storage; keep away from oxidants and strong acids.
- Safety: Operate in a well-ventilated and dry environment; wear sterile protective gear (gloves, goggles, mask); avoid inhalation of dust and skin/eye contact; wash hands thoroughly with soap and water after handling; if accidentally inhaled or in contact with eyes, rinse immediately with plenty of water and seek medical attention if irritation persists; dispose of waste in accordance with pharmaceutical waste regulations.
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