Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Silibinin (CAS: 22888-70-6), also known as Silybin, is the principal biologically active constituent of the silymarin complex (accounting for 65–75%). It is a flavonolignan compound extracted from the dried fruits of the Asteraceae plant Silybum marianum (Milk Thistle). It appears as a pale yellow solid or crystalline powder, odorless, sparingly soluble in water and acetone, and soluble in DMSO and methanol. It has significant hepatoprotective, antioxidant, and anti-inflammatory activities, widely used in pharmaceuticals, health products, and cosmetics.
Uses
Pharmaceutical: A key hepatoprotective drug, used for the treatment of acute and chronic hepatitis, initial cirrhosis, and toxic liver damage. It stabilizes liver cell membranes, promotes liver cell repair and regeneration, and reduces liver enzyme levels. It also shows inhibitory effects on the growth and differentiation of liver, prostate, and breast cancer cells.
Health Products & Nutrition: As a functional ingredient in health supplements, it helps protect liver function, prevent fatty liver, and enhance the body's antioxidant capacity, suitable for people with liver strain and alcohol-induced liver damage.
Other Uses: Used in cosmetics for skin conditioning and antioxidant effects. It also serves as an analytical standard in chemical and pharmaceutical research, and a model compound for studying flavonolignan pharmacology.
Molecular Formula & Structure
- Molecular Formula: C??H??O??
- Molecular Weight: 482.47 g/mol
- IUPAC Name: (2R,3R)-3-(4-Hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[d][1,3]dioxole-6-yl 3,5,7-trihydroxy-4-oxochromen-2-carboxylate
- Synonyms: Silybin; Silybin A; Sylibin; Mepasil
- MDL Number: MFCD00872186
- Chemical Structure: A flavonolignan with a complex structure, containing benzo[d][1,3]dioxole and chromenone moieties. Its SMILES string is C((C@H)1OC2=CC=C((C@@H)3(C@H)(C(C4=C(C=C(C=C4O3)O)O)=O)O)C=C2O(C@@H)1C1C=CC(=C(C=1)OC)O)O
Physical & Chemical Properties
- Appearance: Pale yellow solid or crystalline powder, odorless, no visible impurities.
- Melting Point: 168–178 °C (lit.).
- Specific Rotation: +13° (c = 0.30 in acetone + alcohol, 25 °C).
- Solubility: Sparingly soluble in water (62mg/L at 25.05 °C) and acetone; soluble in DMSO and methanol; insoluble in non-polar solvents.
- Boiling Point: 798.0±65.0 °C (predicted); Density: 1.532±0.08 g/cm3 (predicted).
- Stability: Stable under normal conditions; incompatible with strong oxidants and strong bases; avoid light and moisture.
- Toxicity: Low toxicity; LD?? (intravenous, mouse): 1088mg/kg; irritant (Xi), causes eye/skin/respiratory irritation.
Synthesis & Storage
- Synthesis: Mainly extracted and isolated from the dried fruits of Silybum marianum, purified by chromatography to obtain high-purity silibinin; chemical synthesis method is also available but less commonly used industrially.
- Storage: Sealed in airtight containers; stored under inert atmosphere at -18 °C (long-term); avoid light, moisture, strong oxidants and strong bases; shelf life is 1–2 years under proper storage conditions.
- Safety: Operate in a well-ventilated environment; wear protective gear (N95 mask, gloves, goggles); avoid inhalation, skin and eye contact; rinse with plenty of water if contact occurs; dispose of waste in accordance with relevant regulations.
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