Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Pregna-4,6-diene-3,20-dione (CAS: 1162-56-7) is a steroid compound belonging to the pregnane family, with a core structure of a 21-carbon steroid skeleton containing conjugated double bonds at the 4,6 positions and carbonyl groups at the 3 and 20 positions. It appears as a white to off-white crystalline powder, odorless, slightly soluble in water, and soluble in organic solvents such as ethanol, methanol, and acetone. As a key intermediate in steroid synthesis, it is widely used in the production of pharmaceuticals, especially in the synthesis of corticosteroids and sex hormones, with important application value in the pharmaceutical and chemical industries.
Uses
Pharmaceutical Intermediate: It is a critical intermediate in the synthesis of various steroid drugs, including glucocorticoids, mineralocorticoids, and sex hormones (estrogens, androgens). It serves as a core building block for modifying the steroid skeleton to prepare drugs for treating inflammation, autoimmune diseases, endocrine disorders, and other conditions.
Chemical Research & Development: Used as an analytical standard and model compound in steroid chemistry research, facilitating the study of steroid structure-activity relationships, reaction mechanisms, and synthesis pathways. It is also used in the development of new steroid derivatives with improved biological activity and reduced side effects.
Other Uses: Applied in the research and production of specialty chemicals related to steroids, and serves as a reference material in chemical analysis and quality control processes in pharmaceutical and chemical laboratories.
Molecular Formula & Structure
- Molecular Formula: C??H??O?
- Molecular Weight: 312.44 g/mol
- IUPAC Name: (8R,9S,10R,13S,14S)-10,13-Dimethyl-1,2,3,4,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydrocyclopenta[a]phenanthrene-3,20-dione
- Synonyms: 4,6-Pregnadien-3,20-dione; Pregn-4,6-diene-3,20-dione;
- EINECS Number: 214-604-1
- MDL Number: MFCD00003633
- Chemical Structure: A pregnane steroid with a tetracyclic skeleton (cyclopentanoperhydrophenanthrene), containing conjugated double bonds between C4-C5 and C6-C7, and carbonyl groups (C=O) at C3 and C20. This structural feature is crucial for its reactivity and role as a steroid synthesis intermediate.
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder, odorless, no visible impurities.
- Melting Point: 168–172 °C (lit.)
- Specific Rotation: +195° (c = 0.5 in chloroform, 25 °C)
- Solubility: Slightly soluble in water (≤5 mg/mL at 25 °C), soluble in ethanol, methanol, acetone, chloroform, and other organic solvents; insoluble in non-polar solvents such as hexane.
- Boiling Point: 465.5±45.0 °C (predicted); Density: 1.10±0.1 g/cm3 (predicted, 25 °C)
- Stability: Stable under normal temperature and dry conditions; incompatible with strong oxidants and strong bases; may decompose when heated to high temperatures; avoid light and moisture.
- Toxicity: Low toxicity; LD?? (oral, mouse): >2000 mg/kg; may cause mild irritation to the skin and eyes; avoid direct contact and inhalation.
- UV Absorption: λmax (ethanol) = 280 nm (ε = 15000), a characteristic absorption peak for conjugated carbonyl and double bond structures.
Synthesis & Storage
- Synthesis: Prepared by chemical synthesis methods, typically using pregnenolone or progesterone as the starting material, through dehydrogenation reaction to introduce double bonds at the 6 position, followed by purification steps (such as recrystallization, chromatography) to obtain high-purity products. The industrial synthesis yield is usually 65–75%.
- Storage: Sealed in airtight, light-proof containers; stored under inert atmosphere (nitrogen or argon) at -20 °C (long-term storage); short-term storage can be at 2–8 °C in a dark, dry place. Avoid light, moisture, high temperature, and strong oxidants; shelf life is 2–3 years under proper storage conditions.
- Safety: Operate in a well-ventilated environment; wear professional protective gear (dust mask, gloves, goggles) to avoid inhalation of powder and direct contact with skin and eyes; do not eat, drink, or smoke during operation; wash thoroughly with soap and water after handling; if accidentally inhaled or in contact with eyes, rinse immediately with plenty of water and seek medical advice if irritation persists; dispose of waste in accordance with pharmaceutical or chemical waste regulations.
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