Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
CYTIDINE 5'-DIPHOSPHOCHOLINE (CAS: 987-78-0), commonly abbreviated as CDP-Choline or Citicoline, is a naturally occurring nucleotide derivative composed of cytidine and choline linked by a diphosphate bridge. It appears as a white to almost white crystalline powder, odorless, and is an essential intermediate in the biosynthesis of phosphatidylcholine—a major component of cell membranes—via the Kennedy pathway. This compound is widely used in pharmaceutical R&D, neuroscience research, and clinical applications due to its neuroprotective properties, and also serves as a research reagent in biochemistry and molecular biology studies. It plays a critical role in maintaining cell membrane integrity and enhancing cellular signaling, making it valuable in the research of central nervous system (CNS) disorders.
Uses
Pharmaceutical & Clinical Research: A key compound in the development of neuroprotective agents, used in the research and treatment of CNS disorders such as stroke, dementia, and age-related cognitive decline. It acts as a precursor for phosphatidylcholine synthesis, helping to repair damaged neuronal membranes and improve cognitive function. It is also investigated as an antidepressant and 5HT uptake inhibitor, contributing to the development of psychiatric medications.
Biochemical & Laboratory Research: Used as a research reagent in molecular biology and biochemistry studies, including investigations into cell membrane phospholipid synthesis, neurotransmitter regulation, and the Kennedy pathway. It serves as a reference standard in HPLC-based quality control of pharmaceutical products and is used in in vitro and in vivo experiments to study its role as a human, yeast, and mouse metabolite.
Molecular Formula & Structure
- Molecular Formula: C??H??N?O??P?
- Molecular Weight: 488.33 g/mol
- IUPAC Name: Cytidine 5'-(trihydrogen diphosphate) choline
- Synonyms: CDP-Choline; Citicoline; Cytidine 5'-diphosphocholine;
- EINECS Number: 213-580-7
- MDL Number: MFCD00868097
- SMILES Code: O(C@@H)1(C@@H)((C@@H)(COP(O)(=O)OP((O-))(=O)OCC(N+)(C)(C)C)O(C@H)1N1C=CC(N)=NC1=O)O|&1:1,2,3,21,r|
- Chemical Structure: A nucleotide derivative structure consisting of a cytidine moiety linked to a diphosphate-choline group. It features a ribose sugar, a cytosine base, a diphosphate bridge, and a choline group, which together enable its role as a precursor in phospholipid synthesis and its neuroprotective functions.
Physical & Chemical Properties
- Appearance: White to almost white crystalline powder, odorless, with no visible impurities.
- Density: Not available; Melting Point: >185 °C (decomposes), 209.0–213.0 °C (pure grade).
- Solubility: Sparingly soluble in water; almost transparent in aqueous solutions; compatibility with biological buffers and common laboratory solvents.
- Boiling Point: Not available; Flash Point: Not available.
- Stability: Moisture-sensitive, air-sensitive, and heat-sensitive; stable under inert atmosphere and low-temperature storage; avoid moisture, high temperature, and direct sunlight.
- Toxicity: Low acute toxicity; LD?? (intravenous, mouse): 4600±335 mg/kg, (intravenous, rat): 4150±370 mg/kg; 8 g/kg orally for both species is non-toxic; no obvious irritation, non-carcinogenic and non-mutagenic.
- pKa: 4.4 (at 25 °C); LogP: -7.070 (estimated); PSA: Not available.
Synthesis & Storage
- Synthesis: Industrially prepared via microbial fermentation or chemical synthesis. A typical fermentation method uses Brevibacterium ammonia genes ATCC 6872 with CMP (cytidine-5'-monophosphate), choline, and glucose as raw materials, followed by purification via anion exchange resin and recrystallization to obtain high-purity products.
- Storage: Sealed in airtight, light-proof containers under inert atmosphere; stored at 2–8 °C for short-term storage or -20 °C for long-term storage; avoid moisture, high temperature, and air exposure; shelf life is 2 years under proper storage conditions.
- Safety: Operate in a well-ventilated environment or fume hood; wear basic protective gear (nitrile gloves, goggles, lab coat) to avoid direct contact with skin and eyes; wash thoroughly with soap and water after handling; dispose of waste in accordance with pharmaceutical chemical waste regulations.
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