Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Ethyl Thioglycolate (CAS: 623-51-8), also known as Ethyl Mercaptoacetate or Ethyl 2-Mercaptoacetate, is an organic compound belonging to the ester family with a mercapto (-SH) functional group. It appears as a colorless to almost colorless clear liquid, with a characteristic odor, and is air-sensitive and flammable. This compound is chemically reactive due to the presence of the mercapto group, serving as a key intermediate in organic synthesis, pharmaceutical R&D, and cosmetic formulations. It is also widely used as a research reagent in analytical chemistry and material science.
Uses
Organic Synthesis & Pharmaceutical Intermediates: A critical intermediate for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and fine chemicals. It is used in the preparation of thiol-containing derivatives, which are essential for drug synthesis and chemical process optimization.
Cosmetic & Laboratory Applications: Used in cosmetic formulations for hair waving, straightening, and depilatory products due to its reducing properties. In laboratory settings, it serves as a reference standard in gas chromatography (GC)-based quality control and a reagent in analytical and synthetic experiments.
Molecular Formula & Structure
- Molecular Formula: C?H?O?S
- Molecular Weight: 120.17 g/mol
- IUPAC Name: Ethyl 2-mercaptoacetate
- Synonyms: Ethyl Mercaptoacetate; Ethyl 2-Mercaptoacetate; Thioglycolic Acid Ethyl Ester;
- EINECS Number: 210-800-3
- MDL Number: MFCD00004874
- SMILES Code: CCOC(=O)CS
- Chemical Structure: Consists of an ethyl ester group (-COOC?H?) linked to a methylene group (-CH?-) that is bonded to a mercapto group (-SH). The presence of the mercapto group gives the compound its characteristic reactivity, while the ester group enhances its solubility in organic solvents.
Physical & Chemical Properties
- Appearance: Colorless to almost colorless clear liquid, with a characteristic odor; may darken slightly upon exposure to air.
- Density: 1.096 g/mL at 25 °C (lit.); Melting Point: -80 °C.
- Solubility: Not miscible or difficult to mix in water; soluble in organic solvents such as ethanol, ether, and acetone.
- Boiling Point: 54 °C/12 mmHg (lit.); 157 °C (atmospheric pressure); Flash Point: 48 °C (118 °F).
- Stability: Air-sensitive and flammable; stable under normal temperature and dry conditions when stored properly; incompatible with strong oxidants and strong bases; avoid exposure to air, heat, and ignition sources.
- Toxicity: Toxic if swallowed (GHS Hazard Statement H301); flammable liquid and vapor (H226); may cause skin irritation (H315) and serious eye irritation (H319); proper protective measures are required during handling.
- pKa: 7.95 (SH group, 25 °C); LogP: 1.134 (est.); Refractive Index: n 20/D 1.457 (lit.).
Synthesis & Storage
- Synthesis: Industrially prepared by the esterification reaction of thioglycolic acid with ethanol in the presence of sulfuric acid as a catalyst, followed by purification to achieve the required purity.
- Storage: Sealed in airtight, light-proof containers under inert atmosphere; stored in a cool, dark place (preferably below 15 °C or 2–8 °C); keep locked up; avoid moisture, air, heat, and ignition sources; shelf life is 1–2 years under proper storage conditions.
- Safety: Operate in a well-ventilated fume hood; use explosion-proof electrical, ventilating, and lighting equipment; wear professional protective gear (nitrile gloves, goggles, lab coat, face protection); avoid eating, drinking, or smoking during handling; wash skin thoroughly after contact; in case of fire, use dry sand, dry chemical, or alcohol-resistant foam to extinguish.
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