Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Properties
Appearance: White to off-white crystalline powder, odorless, with uniform texture and no visible impurities. It has strong hygroscopicity, is sensitive to light and air, and is easy to absorb moisture in the air, so it needs to be sealed and stored. It presents as colorless prismatic crystals or crystalline powder in pure form, with a salty acid taste.
Solubility: Easily soluble in water (0.1 g/mL, clear and colorless) and methanol; soluble in ethanol and acetone; very slightly soluble in ether and chloroform. Its aqueous solution is acidic to litmus, and the solubility is stable under normal temperature conditions.
Other properties: It has good crystallinity, and the crystal form is stable under proper storage conditions; purity is usually ≥98% for industrial use and ≥99.0% for laboratory and pharmaceutical use; it has no obvious corrosive effect on common metals and plastics.
Chemical Properties
1. Stability: Stable under normal temperature and pressure; incompatible with strong oxidizing agents, and may decompose when mixed with them; stable to weak acids and weak bases, and can be stored for a long time under proper sealed and light-shielded conditions without obvious deterioration.
2. Reactivity: As a histamine derivative, it is a histamine receptor agonist and vasodilator, which can participate in local immune responses, regulate intestinal physiological functions, and act as a neurotransmitter. It affects the p38 MAPK/Akt signaling pathway, has anti-tumor, anti-oxidant and anti-inflammatory activities, and can be used in the research of related diseases.
3. Incompatibility: Incompatible with strong oxidizing agents; avoid mixed storage with these substances to prevent decomposition or side reactions; stable when mixed with common biochemical reagents and organic solvents.
Usage
1. Biochemical Reagent: Used as a substrate for the determination of histaminase, and is widely used in biochemical experiments and detection fields, such as HPLC determination of histamine levels in organisms.
2. Pharmaceutical Industry: As an important pharmaceutical intermediate, it is used in drug manufacturing; it can also be used in the research of acute myeloid leukemia, malignant melanoma, renal cell carcinoma and other diseases, and can be used to construct gastrointestinal ulcer models in animal experiments.
3. Scientific Research: Used as an orthogonal cotransmitter to generate excitatory postsynaptic potentials (EPSP); used to evaluate the tracheal response of guinea pigs to antigens, and is widely used in neurobiology and immunology research.
4. Other Fields: Used as a raw material for the synthesis of histamine derivatives; used in the research of tyrosine hydroxylase-related products, as a natural isomer of the direct precursor of dopamine.
Storage
Store in a sealed container, keep away from light, moisture and air; store in a cool, dry and well-ventilated warehouse, the recommended storage temperature is 2-8°C. It should be stored separately from strong oxidizing agents, and should not be mixed for storage; avoid long-term exposure to light and high temperature to prevent moisture absorption and deterioration. The storage period can reach 1-2 years under proper storage conditions; the common packaging includes 5g, 500g, 5kg, 25kg/drum, suitable for different usage scenarios.
Safety Overview
Hazard Category: Irritant (Xi, Xn); Hazardous class: Irritant. It causes skin irritation (Category 2), eye irritation (Category 2A), respiratory allergy (Category 1) and skin allergy (Category 1); it has acute oral toxicity (Category 5), LD50 orally in Rabbit: 1550-2534 mg/kg. It is for professional biochemical, pharmaceutical and scientific research use only; it is safe when used in accordance with operating specifications, and is not suitable for household use.
Safety Precautions
1. Personal Protection: Wear disposable gloves, safety goggles and dust mask when handling; avoid direct contact with skin and eyes, and avoid inhalation of dust; ensure adequate ventilation in the operation area, and wash hands thoroughly after handling.
2. Emergency Handling: If contact with skin, rinse thoroughly with plenty of flowing water for 5-10 minutes; if contact with eyes, rinse cautiously with water for several minutes (remove contact lenses if present) and continue rinsing, seek medical advice immediately if discomfort occurs; if inhaled, move to fresh air immediately, keep the respiratory tract unobstructed, and seek medical advice if discomfort occurs; if swallowed, drink plenty of water to dilute, call a poison center or doctor immediately.
3. Fire & Spill: Low flammability; use dry powder, foam or carbon dioxide fire extinguishing agents in case of fire; if spilled, isolate the contaminated area, wear protective equipment, collect the spilled powder with dry and clean tools, put it into a sealed container for proper disposal, and avoid entering drains or water courses.
4. Disposal: Dispose of waste and packaging in accordance with local environmental and hazardous waste regulations; do not discard at will; waste must be treated by professional hazardous waste disposal institutions to avoid environmental pollution; transport in accordance with the regulations of hazardous goods (UN 3335).
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