Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Properties
Appearance: White to off-white crystalline powder, odorless, with uniform texture and no visible impurities. It has good crystallinity, presents as fine needle-like or flaky crystals in pure form, slightly sensitive to light and air, and may turn slightly yellow if exposed to light for a long time, so it needs to be stored away from light. It has no obvious odor and stable physical state under normal storage conditions.
Solubility: Slightly soluble in water; easily soluble in ethanol, methanol, acetone and chloroform; soluble in ethyl acetate and dioxane; slightly soluble in ether and petroleum ether. Its solubility in organic solvents is better than that in water, which is a typical characteristic of steroid compounds, and it is easy to dissolve in polar organic solvents for experimental and production operations.
Other properties: It has a specific optical rotation of [α]20/D +58° to +64° (c=1, ethanol); purity is usually ≥98% for industrial use and ≥99.0% for laboratory and pharmaceutical use; it has no obvious corrosive effect on common metals and plastics, and is stable in neutral and weak acid environments.
Chemical Properties
1. Stability: Stable under normal temperature and pressure; stable to weak acids and weak bases; incompatible with strong oxidizing agents and strong reducing agents, and may decompose when mixed with them; stable under proper sealed and light-shielded conditions, and can be stored for a long time without obvious deterioration. It is not easy to hydrolyze under normal conditions, and the chemical structure is stable.
2. Reactivity: As a natural progesterone derivative and steroid hormone, it has typical progesterone-like biological activity, can regulate the growth and secretion of endometrium, inhibit ovulation, and participate in the regulation of female reproductive system functions. It can undergo acylation, oxidation, reduction and other reactions, and is an important intermediate for the synthesis of various steroid drugs, such as synthetic progesterone and anti-tumor steroid drugssuperscript:2superscript:3>.
3. Incompatibility: Incompatible with strong oxidizing agents, strong reducing agents and strong bases; avoid mixed storage with these substances to prevent decomposition or side reactions; stable when mixed with common organic solvents, biochemical reagents and pharmaceutical excipients, and has good compatibility.
Usage
1. Pharmaceutical Industry: As a key pharmaceutical intermediate, it is used in the synthesis of various steroid drugs, such as medroxyprogesterone acetate, hydroxyprogesterone caproate, etc. These drugs are widely used in the treatment of menstrual disorders, functional uterine bleeding, endometriosis, and palliative treatment of hormone-sensitive tumors (such as endometrial cancer, breast cancer, prostate cancer)superscript:2superscript:3superscript:11>.
2. Biochemical Reagent: Used as a standard substance and substrate in biochemical experiments, such as the determination of progesterone levels in organisms by HPLC, the research of steroid hormone metabolism pathways, and the detection of related enzymes. It is widely used in neurobiology, endocrinology and reproductive biology research.
3. Scientific Research: Used in the research of female reproductive system diseases, such as the research of polycystic ovary syndrome and threatened abortion; used to study the regulatory mechanism of steroid hormones on the body, and provide a basis for the development of new steroid drugs. It can also be used in the research of hormone-sensitive tumor treatment mechanisms.
4. Other Fields: Used as a raw material for the synthesis of steroid hormone derivatives; used in the research of hormone replacement therapy, and plays an important role in the research of menopausal syndrome treatmentsuperscript:2superscript:3>.
Storage
Store in a sealed container, keep away from light, moisture and air; store in a cool, dry and well-ventilated warehouse, the recommended storage temperature is 2-8°C (refrigerated storage)superscript:7superscript:9. It should be stored separately from strong oxidizing agents, strong reducing agents and strong bases, and should not be mixed for storage; avoid long-term exposure to light and high temperature to prevent discoloration and deterioration. The storage period can reach 1-2 years under proper storage conditions; the common packaging includes 1g, 10g, 100g, 1kg, 25kg/drum, suitable for laboratory research and industrial production.
Safety Overview
Hazard Category: Irritant (Xi); Hazardous class: Irritant. It causes mild skin irritation (Category 2) and eye irritation (Category 2A); low acute toxicity, LD50 orally in Rat: >5000 mg/kg, LD50 dermal in Rabbit: >2000 mg/kg. It is a steroid hormone substance, which may have endocrine-disrupting effects if used improperly; it is for professional pharmaceutical, biochemical and scientific research use only; it is safe when used in accordance with operating specifications, and is not suitable for household use.
Safety Precautions
1. Personal Protection: Wear disposable gloves, safety goggles and dust mask when handling; avoid direct contact with skin and eyes, and avoid inhalation of dust; ensure adequate ventilation in the operation area, and wash hands thoroughly after handling. Avoid long-term direct contact to prevent potential endocrine effects.
2. Emergency Handling: If contact with skin, rinse thoroughly with plenty of flowing water for 5-10 minutes; if contact with eyes, rinse cautiously with water for several minutes (remove contact lenses if present) and continue rinsing, seek medical advice if discomfort occurs; if inhaled, move to fresh air immediately, keep the respiratory tract unobstructed, and seek medical advice if discomfort occurs; if swallowed, drink plenty of water to dilute, call a poison center or doctor immediately.
3. Fire & Spill: Low flammability; use dry powder, foam or carbon dioxide fire extinguishing agents in case of fire; if spilled, isolate the contaminated area, wear protective equipment, collect the spilled powder with dry and clean tools, put it into a sealed container for proper disposal, and avoid entering drains or water courses to prevent environmental pollution.
4. Disposal: Dispose of waste and packaging in accordance with local environmental and hazardous waste regulations; do not discard at will; waste must be treated by professional hazardous waste disposal institutions to avoid environmental pollution; transport in accordance with the regulations of hazardous goods, avoid mixing with incompatible substances during transportation.
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