Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Epitestosterone, also known as 17α-testosterone, is a naturally occurring endogenous steroid hormone and the 17α-epimer of testosterone. It appears as white to off-white crystalline powder, odorless, with good chemical stability under normal storage conditions. It is insoluble in water, soluble in organic solvents such as ethanol, chloroform, and acetone, and plays important roles in biochemistry, clinical medicine, and sports anti-doping detection. As a weak androgen, it has no significant androgenic activity but is widely used as a reference standard and intermediate in pharmaceutical and biochemical research.
Uses
Clinical & Biochemical Research: Serves as a reference standard for detecting testosterone levels in human body fluids (blood, urine), helping diagnose endocrine disorders such as hypogonadism and hyperandrogenism. It is also used to study the metabolic pathways of steroid hormones in the human body.
Sports Anti-Doping Detection: As a key marker in anti-doping testing, the ratio of testosterone to epitestosterone (T/E ratio) is used to identify artificial testosterone abuse by athletes. A normal T/E ratio is around 1:1, and values exceeding 4:1 are considered suspicious for doping.
Pharmaceutical Intermediate: Used in the synthesis of various steroid drugs, including androgens, estrogens, and anti-inflammatory steroids, providing a key structural skeleton for drug development. It can also be used to prepare steroid hormone derivatives for studying structure-activity relationships.
Biomedical Research: Applied in studies on the regulation of steroid hormone receptors, cell proliferation, and reproductive system function. It is also used as a control substance in immunoassays (such as ELISA) for steroid hormone detection.
Molecular Formula & Structure
- Molecular Formula: C??H??O?
- Molecular Weight: 286.44 g/mol
- IUPAC Name: (17α)-17-hydroxyandrost-4-en-3-one
- Synonyms: 17α-Testosterone; 17α-Hydroxyandrost-4-en-3-one;
- EC Number: 207-566-1
- SMILES Code: C[C@]12CC[C@H]3[C@H](CC[C@@H]4[C@@]3(C[C@@H](O)CC4)O)C1CCC2=O
- Chemical Structure: A steroid compound with a cyclopentanoperhydrophenanthrene skeleton, containing a hydroxyl group (-OH) at the 17α position and a carbonyl group (C=O) at the 3 position, with a double bond between C4 and C5. It is the stereoisomer of testosterone, differing only in the configuration of the hydroxyl group at the 17th carbon atom.
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder, odorless, no visible impurities, no caking.
- Melting Point: 183–187 °C; Specific Rotation: +102° to +108° (c=1, ethanol, 25 °C).
- Boiling Point: Decomposes above 360 °C (no obvious boiling point, decomposes at high temperature); Flash Point: 209 °C (closed cup), non-flammable.
- Solubility: Insoluble in water; soluble in ethanol, methanol, chloroform, acetone, and dioxane; slightly soluble in ether and petroleum ether.
- Stability: Stable under normal temperature and pressure, away from light and moisture; decomposes when exposed to strong oxidizing agents, strong acids, or high temperatures; sensitive to light, easy to discolor when exposed to sunlight for a long time.
- Toxicity: Low toxicity; acute oral toxicity is low, but long-term or high-dose exposure may cause endocrine disruption; irritating to skin and eyes; avoid direct contact and inhalation of dust.
Synthesis & Storage
- Synthesis: There are two main methods: 1. Extraction from natural sources: Isolated and purified from human urine or animal tissues (such as testes), but the yield is low; 2. Chemical synthesis: Prepared by stereoselective oxidation or reduction of testosterone, or by cyclization of steroid intermediates (such as androstenedione), with high yield and suitable for industrial production.
- Storage: Sealed in airtight, light-proof, moisture-proof containers; stored in a cool, dry, dark place (recommended storage temperature 2–8 °C); avoid light, moisture, high temperature, and contact with incompatible substances (strong oxidizing agents, strong acids); shelf life is 24 months when unopened and stored properly.
- Safety: Operate in a well-ventilated fume hood; wear professional protective gear (nitrile gloves, goggles, lab coat, and dust mask); avoid inhalation of dust and direct skin/eye contact; if in contact with skin, rinse with plenty of water; if in contact with eyes, rinse with water for at least 15 minutes and seek medical advice; keep away from food, feed, and children; dispose of waste in accordance with relevant environmental regulations.
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