Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Ethyl 2-hydroxybenzoate, also known as ethyl salicylate or salicylic acid ethyl ester, is an organic ester compound formed by the condensation of salicylic acid and ethanol. It appears as a colorless to light yellow clear oily liquid at room temperature, with a characteristic wintergreen-like pleasant odor. It is sparingly soluble in water but soluble in most organic solvents, and is widely used as a flavoring agent, fragrance ingredient, pharmaceutical intermediate, and solvent in food, cosmetic, pharmaceutical, and chemical synthesis fields.
Uses
Food Industry: Serves as an artificial flavoring agent, mainly used to prepare berry flavors (such as blackberry, black currant, and strawberry) and artificial cinnamon oil, adding a unique wintergreen aroma to food products like candies, beverages, and pastries.
Cosmetic & Fragrance Industry: Incorporated into daily chemical products such as soaps, perfumes, and skincare products as a fragrance ingredient, providing a fresh and pleasant wintergreen scent. It is also used in the formulation of daily use soap essence to enhance aroma persistence.
Pharmaceutical Field: Acts as a key pharmaceutical intermediate for the synthesis of various salicylate derivatives and other pharmaceutical compounds. It also has mild antipyretic and analgesic potential and is used in the development of related pharmaceutical formulations.
Chemical & Biochemical Research: Used as a solvent for nitrocellulose and other materials. In biochemical research, it is used as a reference standard and reaction reagent in organic synthesis reactions, supporting the preparation of various ester derivatives and related compounds.
Molecular Formula & Structure
- Molecular Formula: C?H??O?
- Molecular Weight: 166.18 g/mol
- IUPAC Name: Ethyl 2-hydroxybenzoate
- Synonyms: Ethyl salicylate; Salicylic acid ethyl ester; 2-Hydroxybenzoic acid ethyl ester MFCD00002215
- EC Number: 204-258-6
- SMILES Code: O=C(OCC)C1=CC=CC=C1O
- Chemical Structure: An ester compound consisting of a benzene ring substituted with a hydroxyl group (-OH) at the 2-position and a carboxylate ethyl group (-COOC?H?) at the 1-position. Its unique structure endows it with characteristic aroma and chemical reactivity, being the esterification product of salicylic acid and ethanol.
Physical & Chemical Properties
- Appearance: Colorless to light yellow clear oily liquid, with a characteristic wintergreen odor; gradually turns yellowish-brown when exposed to light or stored for a long time in air.
- Melting Point: 1–3 °C (solid below 1 °C, liquid above 1 °C); Boiling Point: 231–234 °C; Flash Point: 107–120 °C (closed cup).
- Density: 1.125–1.132 g/cm3 (20/20 °C or 25/25 °C); Refractive Index: 1.518–1.5296 (20 °C).
- Solubility: Sparingly soluble in water; soluble in ethanol, ether, chloroform, and other organic solvents; soluble in DMSO (200 mg/mL, need ultrasonic).
- Stability: Stable under normal temperature and pressure; avoid contact with oxidizing agents. Sensitive to light, easy to discolor when exposed to sunlight; stable when stored in a cool, dark environment.
- Toxicity: Harmful if swallowed; causes skin and serious eye irritation, may cause respiratory discomfort. Oral LD50 (rat) is moderate; avoid inhalation of vapors and direct skin/eye contact.
Synthesis & Storage
- Synthesis: Prepared by esterification reaction of salicylic acid and ethanol under the catalysis of concentrated sulfuric acid or other acid catalysts, followed by neutralization, extraction, distillation, and purification to obtain the pure product.
- Storage: Sealed in airtight, light-resistant containers; stored in a cool, dry, well-ventilated place (recommended storage temperature <15 °C or room temperature in a dark environment). Keep away from fire, heat sources, and oxidizing agents; avoid mixing with incompatible substances. Shelf life: 3 years at room temperature (unopened); 2 years at -80 °C when dissolved in solvent; 1 year at -20 °C.
- Safety: Operate in a well-ventilated fume hood; wear nitrile gloves, goggles, and face protection. Avoid eating, drinking, or smoking during operation; wash skin thoroughly after handling. In case of skin contact, wash with plenty of water and soap; in case of eye contact, rinse cautiously with water for several minutes and seek medical advice if irritation persists. Dispose of waste in accordance with relevant environmental regulations.
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