Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
DL-2-Aminobutyric acid, also known as DL-α-aminobutyric acid or DL-2-aminobutanoic acid, is a racemic mixture of D-2-aminobutyric acid and L-2-aminobutyric acid, belonging to the class of α-amino acids. It appears as a white to slightly off-white crystalline powder at room temperature, with a very faint caramellic-sweet odor. It is highly soluble in water, poorly soluble in ethanol and acetone, and insoluble in oils. Due to its unique chiral structure and chemical properties, it is widely used as a pharmaceutical intermediate, peptide synthesis reagent, and reference material in pharmaceutical, biochemical research, and organic synthesis fields.
Uses
Pharmaceutical Field: Serves as a key pharmaceutical intermediate for the synthesis of various bioactive compounds, chiral drugs, and peptide drugs. It can be resolved into D-2-aminobutyric acid and L-2-aminobutyric acid, both of which are important chiral reagents and raw materials for drug development, playing a crucial role in the synthesis of antiviral, antibacterial, and other therapeutic agents.
Biochemical Research: Used as a reference standard and reaction reagent in amino acid research, peptide synthesis, and biochemical assays. It is also employed in the study of amino acid metabolism and as a component in cell culture media, supporting the research of biological processes and molecular biology experiments.
Chemical Synthesis: Acts as a chiral building block in organic synthesis, used to prepare chiral intermediates, fine chemicals, and specialty materials. Its amino and carboxyl functional groups enable various chemical reactions, making it valuable in the synthesis of complex organic compounds.
Other Fields: Used as a raw material in the production of food additives and feed supplements, providing essential amino acid nutrition. It also serves as a standard substance in analytical chemistry for the calibration of detection instruments and methods.
Molecular Formula & Structure
- Molecular Formula: C?H?NO?
- Molecular Weight: 103.12 g/mol
- IUPAC Name: 2-Aminobutanoic acid
- Synonyms: DL-α-Aminobutyric acid; DL-2-Aminobutanoic acid; DL-α-Amino-n-butyric acid;MFCD00008093; CB4382245; BRN 635889
- EC Number: 220-616-5
- SMILES Code: CCC(N)C(O)=O
- Chemical Structure: An α-amino acid with a linear four-carbon chain, featuring an amino group (-NH?) and a carboxyl group (-COOH) attached to the same carbon atom (the 2-position). As a racemic mixture, it contains equal amounts of the D and L enantiomers, with the chemical structure CH?CH?CH(NH?)COOH, which endows it with typical amino acid chemical reactivity.
Physical & Chemical Properties
- Appearance: White to slightly off-white crystalline powder, with a very faint caramellic-sweet odor; stable in appearance under proper storage conditions.
- Melting Point: 291–304 °C (decomposes); Specific Rotation: (α)D2? 0.0±0.1° (c=10, H?O); Boiling Point: 215.2±23.0 °C (predicted).
- Density: 1.230 g/cm3 (estimate); Refractive Index: 1.4650 (estimate, 20 °C); pKa: 2.29 (at 25 °C).
- Solubility: Highly soluble in water (210 g/L, 33% in cold water), poorly soluble in ethanol and acetone, insoluble in oils; aqueous solution is almost transparent, with a pH value of approximately 5.98.
- Stability: Stable under normal temperature and pressure; should be stored in an inert atmosphere to avoid oxidation. It is stable in a cool, dry, and dark environment, and should be kept away from strong oxidants, strong acids, and strong alkalis to prevent chemical reactions and deterioration.
- Toxicity: Harmful if swallowed, inhaled, or in contact with skin and eyes (GHS hazard class 07). It may cause irritation to the respiratory tract, skin, and eyes; avoid inhalation of dust and direct contact with skin and eyes.
Synthesis & Storage
- Synthesis: Prepared by several methods, including the Strecker synthesis (using propionaldehyde, ammonium cyanide, and ammonium carbonate as raw materials, followed by hydrolysis) and the catalytic amination of 2-oxobutanoic acid. It can also be obtained by resolving the racemic mixture from natural sources or chemical synthesis.
- Storage: Sealed in airtight, light-resistant containers under an inert atmosphere; stored in a cool, dry, well-ventilated place (recommended storage temperature <15 °C in a cool and dark environment). Keep away from fire, heat sources, strong oxidants, strong acids, and strong alkalis; avoid direct sunlight and moisture. Shelf life: 24 months when unopened and stored properly.
- Safety: Operate in a well-ventilated fume hood; wear nitrile gloves, goggles, lab coat, and dust mask. Avoid eating, drinking, or smoking during operation; wash skin thoroughly after handling. In case of skin contact, wash with plenty of water and soap; in case of eye contact, rinse cautiously with water for several minutes and seek medical advice if irritation persists. Dispose of waste in accordance with relevant environmental regulations.
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