Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
3-Amino-1-hydroxyadamantane (CAS: 702-82-9), also called 3-Amino-1-adamantanol, is a high-purity alicyclic amino alcohol with a rigid adamantane structure. It is a white to off-white or light yellow crystalline powder with hydroxyl and amino groups, slightly soluble in DMSO and methanol, insoluble in water. Mainly synthesized via three industrial methods, it is a key pharmaceutical intermediate for anti-type 2 diabetes drugs and used in organic synthesis and material science.
Uses
Pharmaceutical Industry: Core raw material for synthesizing vildagliptin and other adamantane derivative drugs, with bifunctional groups enabling various chemical reactions.
Organic Synthesis: Key building block for adamantane derivatives, applicable to acylation, alkylation and condensation reactions.
Material Science: Used in R&D of modified polymers, corrosion inhibitors and chiral catalysts, enhancing material stability and mechanical properties.
Laboratory Research: Chemical reagent for organic synthesis and scientific research in medicinal and organic chemistry.
Molecular Formula & Structure
- Molecular Formula: C??H??NO
- IUPAC Name: (1S,3R,5R,7S)-3-Aminoadamantan-1-ol
- Synonyms: 3-Amino-1-adamantanol; 1-Amino-3-hydroxyadamantane; MFCD01821204; InChIKey: DWPIPTNBOVJYAD-UHFFFAOYSA-N
- CAS Number: 702-82-9
- SMILES Code: C12(O)CC3CC(CC(N)(C3)C1)C2
- Chemical Structure: Tricyclic alicyclic compound with adamantane core, hydroxyl at 1-position and amino at 3-position, ensuring stability and reactivity.
Physical & Chemical Properties
- Appearance: White to off-white or light yellow crystalline powder, odorless, no visible impurities.
- Melting Point: 265°C (decomposition); Boiling Point: 266.8±23.0°C (predicted); Density: 1.252±0.06 g/cm3 (25°C); Flash Point: 230 °F.
- Solubility: Insoluble in water; slightly soluble in DMSO/methanol; soluble in ethanol, acetone, chloroform; pKa: 15.07±0.40 (predicted).
- Stability: Stable under normal conditions; incompatible with strong oxidants, acids and bases; avoid high temperature (>100°C) and humidity.
- Toxicity & Safety: Irritating to skin, eyes and respiratory tract (GHS07); no carcinogenic/mutagenic effects; handle with caution.
Synthesis & Storage
- Synthesis: Mainly via adamantamine method (mainstream), 3-bromo-1-adamantane carboxylic acid method and 3-acetamidoadamantanol method; crude product purified by recrystallization.
- Storage: Store at 15–25°C in cool, dry, well-ventilated, dark and inert environment; sealed packaging; shelf life 24 months if unopened.
- Handling Precautions: Use in well-ventilated areas with protective equipment; avoid contact and dust generation; dispose of waste as per local regulations.
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