Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Benzylmagnesium chloride (CAS: 6921-34-2), abbreviated as BnMgCl, is a high-purity organomagnesium Grignard reagent with the formula C?H?ClMg. It is typically supplied as a colorless to pale yellow or brownish clear solution in anhydrous organic solvents such as diethyl ether or tetrahydrofuran (THF), with common concentrations of 1mol/L and 2mol/L. Characterized by strong nucleophilicity and basicity, it is synthesized via the reaction of benzyl chloride with magnesium metal in anhydrous solvents under inert atmosphere. It is widely used in organic synthesis for introducing benzyl groups into target molecules, serving as a key reagent in laboratory research and fine chemical production.
Uses
Organic Synthesis: Core reagent for nucleophilic addition reactions, reacting with aldehydes, ketones, esters, lactones, and carbon dioxide to synthesize benzyl-substituted alcohols, carboxylic acids, and other functional compounds. It also acts as a strong base for deprotonation reactions, facilitating subsequent functionalization of organic substrates.
Pharmaceutical & Fine Chemicals: Key intermediate for synthesizing pharmaceutical raw materials, fragrances, and fine chemicals, such as benzylmethanol and dimethylbenzylcarbinol, which are widely used in drug and perfume formulations.
Laboratory Research: Essential reagent in organic chemistry laboratories for reaction optimization, structural modification, and the synthesis of complex organic molecules, serving as a standard Grignard reagent for teaching and scientific research purposes.
Fine Chemical Production: Applied in the synthesis of specialty chemicals, including aromatic alcohols, ketones, and carboxylic acids, with industrial-grade products available to meet large-scale production needs.
Molecular Formula & Structure
- Molecular Formula: C?H?ClMg
- Molecular Weight: 150.89 g/mol
- IUPAC Name: Benzylmagnesium chloride
- Synonyms: BnMgCl; Benzyl magnesium chloride; MFCD00000469; EC Number: 230-039-0; RTECS Number: OM3500000; UN Number: 3399; Customs Code: 2931900090.
- CAS Number: 6921-34-2
- SMILES Code: (Cl-).[Mg+]Cc1ccccc1
- Chemical Structure: An organometallic compound consisting of a benzyl group (C?H?CH?-) bonded to a magnesium atom, which is further bonded to a chlorine atom. In solution, it exists as a coordination complex with solvent molecules (ether or THF) coordinating to the magnesium atom, enhancing its stability. The polar C-Mg bond endows the compound with strong nucleophilicity, making it highly reactive in organic synthesis reactions.
Physical & Chemical Properties
- Appearance: Colorless to pale yellow or brownish clear solution (in ether or THF); may form slight precipitation under cold conditions, which can be dispersed by shaking or gentle heating; no visible impurities.
- Density: 1.03–1.07 g/cm3 (25°C, THF solution); Viscosity: 50–500 cps (25°C, depending on concentration); Flash Point: -40°C (ethyl ether solution), highly flammable; pKa: Not clearly reported; Decomposition Temperature: ~120°C (in solution).
- Solubility: Insoluble in water (reacts violently with water); miscible with anhydrous organic solvents such as diethyl ether, THF, and toluene; incompatible with protic solvents (alcohols, acids, water) and polar solvents that can react with Grignard reagents.
- Stability: Highly moisture-sensitive and air-sensitive; decomposes rapidly when exposed to water, air, or carbon dioxide, releasing flammable toluene gas. Stable under anhydrous, inert atmosphere (nitrogen or argon); avoid prolonged exposure to light and high temperature (>30°C).
Synthesis & Storage
- Synthesis: Main industrial and laboratory method: Benzyl chloride reacts with magnesium powder or magnesium turnings in anhydrous diethyl ether or THF under inert atmosphere (nitrogen or argon), with no catalyst required; the reaction proceeds spontaneously to form benzylmagnesium chloride solution. The product is used directly as a solution without further purification, and its concentration is determined by titration.
- Storage: Store at <15°C in a cool, dry, well-ventilated, dark warehouse; keep in sealed, airtight containers under inert atmosphere (nitrogen-filled) to prevent contact with moisture and air. Packed in 250mL, 1L, 5L sealed bottles (for laboratory use) or 25kg sealed drums (for industrial use), using dual-seal packaging to ensure airtightness. Avoid direct sunlight, high temperature (>30°C), and contact with water, protic solvents, and strong oxidants; keep away from ignition sources, food, and feed. Shelf life: 12 months if unopened and stored properly under anhydrous, inert conditions.
- Handling Precautions: Use in a well-ventilated fume hood; wear full protective equipment (nitrile gloves, safety goggles, flame-retardant lab coat, face shield). Strictly avoid contact with water, air, acids, and alcohols. In case of skin contact, immediately rinse with plenty of dry sand or inert absorbent (do not use water), then wipe with organic solvent and seek medical attention; in case of eye contact, immediately flush with large amounts of water for 15 minutes and seek medical attention. Dispose of waste in accordance with local regulations: dilute with double the amount of toluene, add ethyl acetate dropwise under ice cooling, then add 10% ammonium chloride solution, separate layers, neutralize the aqueous layer, and dispose of both layers properly. Do not pour directly into drains or mix with other wastes.
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