Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Isoprinosine (CAS: 36703-88-5), also known as Inosine pranobex, is a high-purity synthetic immunostimulant and antiviral agent with the formula C??H??N?O?·C?H?O?. It appears as a white to off-white crystalline powder, odorless, with a slightly bitter taste. It is synthesized by the condensation reaction of inosine with N,N-dimethylamino-2-propanol and p-acetamidobenzoic acid, followed by salification with citric acid. As a broad-spectrum antiviral and immunomodulator, it is widely used in clinical medicine, pharmaceutical research, and laboratory studies, mainly for enhancing immune function and treating viral infections.
Uses
Clinical Medicine: Used for the treatment of viral infections such as herpes simplex, varicella-zoster, and viral hepatitis, as well as for improving immune function in patients with immunodeficiency diseases (e.g., chronic fatigue syndrome, immunocompromised due to chemotherapy). It is also used as an adjuvant therapy for certain bacterial infections to enhance the body's resistance.
Pharmaceutical Research: Serves as a standard reference substance and intermediate in the research and development of immunostimulant drugs, helping to optimize drug formulations and study the mechanism of immune regulation and antiviral action.
Laboratory Research: Applied in biochemical and pharmacological experiments to study the effects of immunostimulants on immune cell function, viral replication, and immune response, with strict restrictions for laboratory use only (not for drug or household use without clinical approval).
Veterinary Medicine: In some regions, it is used as a veterinary drug adjuvant to enhance the immune function of animals and prevent viral infections in livestock and poultry, improving animal health and production performance.
Molecular Formula & Structure
- Molecular Formula: C??H??N?O?·C?H?O? (Inosine pranobex citrate)
- Molecular Weight: 514.43 g/mol
- IUPAC Name: 9-(2,3-Dihydroxypropyl)hypoxanthine 4-acetamidobenzoate 2-(dimethylamino)propan-1-ol citrate
- Synonyms: Inosine pranobex; Isoprinosine citrate; Methisoprinol; Inosiplex; MFCD00078139; EC Number: 253-178-8; RTECS Number: XH2800000; UN Number: 3249; Customs Code: 2934999090.
- CAS Number: 36703-88-5
- SMILES Code: O=C(C(=O)O)C(=O)O.CN(C)CC(O)O.CC(=O)NC1=CC=C(C=C1)C(=O)O.C1=NC2=C(N1)C(=O)N(C(=O)N2)C(C(OH)CH2OH)
- Chemical Structure: A complex compound composed of inosine, p-acetamidobenzoic acid, N,N-dimethylamino-2-propanol, and citric acid. The inosine moiety is the core functional group responsible for its immunomodulatory and antiviral activities, while the citrate salt form improves its water solubility and bioavailability. It acts by enhancing the proliferation and activity of T lymphocytes, B lymphocytes, and natural killer cells, thereby regulating the immune system and inhibiting viral replication.
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder; odorless; slightly bitter taste; no visible impurities. Its aqueous solution is clear and colorless, which should not be used if discolored or containing particulate matter.
- Density: 1.45–1.50 g/cm3 (rough estimate); Melting Point: 183–187°C (dec.); Boiling Point: Not clearly reported (decomposes before boiling); Flash Point: >100°C (non-flammable solid); pKa: Approximately 4.5 (citrate moiety).
- Solubility: Freely soluble in water (≥100 mg/ml at 25°C); slightly soluble in ethanol; insoluble in chloroform, ether, and other non-polar organic solvents. Aqueous solutions are stable under neutral conditions, and decompose when exposed to strong acids or alkalis.
- Stability: Stable under normal temperature and pressure (15–25°C); slightly hygroscopic; decomposes at temperatures above 187°C, releasing toxic fumes. Incompatible with strong oxidants, strong acids, and strong bases; avoid prolonged exposure to sunlight and high temperature.
Synthesis & Storage
- Synthesis: Industrial production involves three main steps: 1) Condensation of inosine with p-acetamidobenzoic acid to form an intermediate; 2) Reaction of the intermediate with N,N-dimethylamino-2-propanol to form the base compound; 3) Salification with citric acid, followed by recrystallization from ethanol-water mixture to obtain high-purity isoprinosine.
- Storage: Store in a cool, dry, well-ventilated warehouse at 15–25°C; keep tightly sealed in light-resistant containers to prevent moisture absorption and light exposure. Packed in 10g, 50g, 250g sealed glass bottles (laboratory grade) or 25kg cardboard drums lined with polyethylene bags (industrial grade). Avoid direct sunlight, high temperature (>30°C), and contact with oxidants, strong acids, and strong bases; keep away from food, feed, and children. Shelf life: 24 months if unopened and stored properly.
- Handling Precautions: Use in a well-ventilated area; wear nitrile gloves, safety goggles, and protective clothing. Avoid inhalation of dust and contact with skin and eyes. It is relatively low-toxic, but prolonged or excessive contact may cause skin irritation. In case of skin contact, rinse thoroughly with plenty of water; in case of eye contact, flush with water for 15 minutes and seek medical attention if irritation persists. In case of ingestion, drink plenty of water and seek medical attention. Dispose of waste in accordance with local regulations; do not discharge directly into the environment or sewers.
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