Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Product Description
Hexarelin (CAS: 140703-51-1), also known as Examorelin, is a potent synthetic hexapeptide and a growth hormone secretagogue (GHS). It has the molecular formula C??H??N??O?, appearing as a white to off-white lyophilized powder with high biological activity. It is mainly used in pharmaceutical research, laboratory R&D and biochemical synthesis, featuring unique cardioprotective effects besides its growth hormone-releasing properties.
Uses
Pharmaceutical Research: A promising candidate for cardiovascular disease research, with cardioprotective effects including improving cardiac contractility, reducing myocardial infarct size and attenuating cardiac fibrosis.
Laboratory R&D: Widely used in biochemical and pharmacological research to study growth hormone secretion mechanisms and the role of GHS-R 1a and CD36 receptors.
Biochemical Synthesis: Used as an active raw material in peptide synthesis, supporting the development of related pharmaceutical products and research reagents.
Molecular Formula & Structure
Chemical Substance Information
Hexarelin is a synthetic hexapeptide chemical substance, belonging to the class of growth hormone secretagogues (GHS). It is stable under proper storage conditions, with low to moderate hygroscopicity; strict handling and storage procedures are required to maintain its biological activity and avoid degradation.
- Molecular Formula: C??H??N??O?
- Molecular Weight: 887.04 g/mol
- CAS Number: 140703-51-1
- Synonyms: Examorelin; EP-23905; MF-6003; L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysine amide; UNII: 09QF37C617.
- Chemical Structure: A synthetic hexapeptide with the amino acid sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH?, containing D-amino acids and methylation modification at position 2, which enhances its stability and biological potency.
Physical & Chemical Properties
- Appearance: White to off-white lyophilized powder, fine and uniform, odorless.
- pH Value: 5.0-7.0 (1% aqueous solution); Hygroscopicity: Low to moderate; Solution Stability: Stable at 4°C for 10-14 days.
- Solubility: Soluble in water or bacteriostatic water at ≥1 mg/mL; slightly soluble in organic solvents such as ethanol; insoluble in non-polar organic solvents like ether and benzene.
- Stability: Stable when stored under desiccated, light-protected conditions at -20°C; prone to degradation when exposed to moisture, high temperature or light; incompatible with strong oxidizing agents and strong acids.
Synthesis & Storage
- Synthesis: Produced through advanced solid-phase peptide synthesis (SPPS) technology, with strict sequence verification and purification steps to ensure high purity and biological activity; the process involves amino acid condensation, deprotection and lyophilization.
- Storage: Lyophilized form should be stored at -20°C in desiccated, light-resistant and airtight containers; reconstituted solution can be stored at 2-8°C for up to 14 days or -20°C for up to 3 months; avoid repeated freezing and thawing; shelf life is 24-36 months when stored properly.
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