Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Information
- CAS Number: 623-47-2
- Molecular Formula: C?H?O?
- Molecular Weight: 98.10 g/mol
- Synonyms: Ethyl prop-2-ynoate; Ethyl acetylenecarboxylate; 2-Propynoic acid ethyl ester; Ethyl propargylate
- Classification: Organic intermediate, pharmaceutical intermediate, chemical reagent, synthetic building block
- EINECS Number: 210-795-8
Physical & Chemical Properties
- Appearance: Clear, colorless to pale yellow transparent liquid with a characteristic fruity or pungent odor; no visible impurities.
- Melting Point: 9°C (48.2°F; 282.1 K); low melting point, easy to solidify at low temperature.
- Boiling Point: 120°C (248°F; 393.1 K) at 760 mmHg; volatile at room temperature.
- Solubility: Miscible with ethanol, ether, chloroform and most organic solvents; slightly soluble in water; insoluble in aliphatic hydrocarbons.
- Stability: Stable under normal storage conditions (2–8°C); flammable; incompatible with strong oxidants, strong bases, acids and heavy metal powders; avoid high temperature and light; easy to polymerize under harsh conditions.
- Key Parameters: Density 0.968 g/mL (25°C); Refractive Index n20/D 1.412 (±0.002); Flash Point 25°C (closed cup); Vapor Pressure 15.5±0.2 mmHg (25°C); Color (APHA) ≤50.
Uses
Ethyl propiolate (CAS: 623-47-2) is a high-activity alkyne compound with wide applications in organic synthesis, pharmaceutical manufacturing and chemical research. As a key organic building block, it is used in the synthesis of various heterocyclic compounds, aromatic derivatives and pharmaceutical intermediates, especially in the preparation of anti-inflammatory, antiviral and anti-tumor drugs. In asymmetric synthesis, its halogenated derivatives serve as substrates for direct asymmetric alkynylation of cyclic β-ketoesters using chiral phase-transfer catalysts. It is also employed in one-pot four-component synthesis of benzene-1,2,3,5-tetracarboxylates promoted by triphenylphosphine. Additionally, it functions as a critical reagent for chemical analysis and material synthesis, meeting high-purity standards for laboratory and industrial applications.
Packaging & Storage
Packaging: Laboratory grade: 10mL/50mL/100mL amber glass bottles (sealed with Teflon gaskets); Industrial grade: 25kg/50kg corrosion-resistant HDPE plastic drums or IBC containers, labeled with "flammable", "irritant" and GHS hazard information, and marked with product name, CAS number, purity and storage conditions. Storage: Store in a cool, dry, well-ventilated warehouse at 2–8°C (refrigerated storage); keep tightly sealed, protected from moisture, light and air; avoid contact with strong oxidants, strong bases, acids and heavy metal powders; shelf life is 12 months under specified storage conditions. Keep away from fire, heat sources and direct sunlight during storage and transportation. Wear chemical-resistant gloves, goggles and protective masks during operation; use in a fume hood to avoid inhalation of vapor or contact with skin and eyes; if it comes into contact with the skin, rinse immediately with plenty of water for at least 15 minutes; if accidentally ingested or splashed into eyes, seek medical attention immediately.
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