Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Information
- CAS Number: 58066-85-6
- Molecular Formula: C??H??NO?P
- Molecular Weight: 407.57 g/mol
- Synonyms: Hexadecylphosphocholine; Hexadecyl 2-(trimethylazaniumyl)ethyl phosphate; 2-(((Hexadecyloxy)hydroxyphosphoryl)oxy)-N,N,N-trimethylethanaminium inner salt; Miltefosine hydrate;
- Classification: Antitumor drug, antileishmanial drug, pharmaceutical raw material, fine chemical raw material, pharmaceutical intermediate, anti-metabolic antitumor drug
- EINECS Number: Not Available
- MDL Number: Not Available
- Beilstein/Reaxys Number: Not Available
- TSCA Status: Not Available
- Customs Code: 2923900090
- Hazard Code: Xn
- Risk Phrases: R22, R43
- Safety Phrases: S36/37
- UN Number: 2811
- Hazard Class: 6.1
- Packing Class: III
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder; odorless; slightly hygroscopic; stable under proper storage conditions, no obvious odor or taste.
- Boiling Point: Not Available (predicted to decompose before boiling); high thermal stability under normal storage conditions, decomposes when heated to melting point.
- Solubility: Soluble in water (10 mg/mL at 20°C), forming a clear and colorless solution; slightly soluble in methanol; insoluble in ethanol, ether, toluene and other organic solvents; solubility in water is stable within a certain temperature range.
- Stability: Stable under ambient conditions; incompatible with strong acids, strong bases and oxidizing agents; avoid excessive heat, direct sunlight and moisture; prone to decomposition when exposed to high temperature and strong light for a long time; metabolized mainly by phospholipase D in vivo, releasing choline, choline-containing metabolites and hexadecanol.
- Key Parameters: Density 1.03±0.06 g/cm3 (25°C, predicted); LogP 6.7; Purity ≥98.0% (HPLC); Water Content ≤5.0%; pH 5.0-8.0 (10% aqueous solution); Loss on Drying ≤5.0%; Residue on Ignition ≤0.1%; Plasma Protein Binding Rate 96%-98% (97% bound to serum albumin, 3% bound to low-density lipoprotein).
Uses
Miltefosine is a synthetic alkylphosphocholine compound with excellent biological activity, widely used in pharmaceutical, medical and biochemical research fields. In pharmaceuticals, it is mainly used as an antileishmanial drug and antitumor drug, which is suitable for adults and adolescents aged 12 and above with a body weight ≥30 kg, effectively treating visceral leishmaniasis caused by Leishmania donovani, cutaneous leishmaniasis caused by Leishmania braziliensis, Leishmania guyanensis and Leishmania panamensis, and mucosal leishmaniasis caused by Leishmania braziliensis. It also has inhibitory effects on a variety of tumor cells and is a PI3K/AKT pathway inhibitor, used in the research and development of antitumor preparations. In biochemical research, it is used as a reagent to study cell signaling pathways and lipid metabolism, often used in kinase experiments (such as caspase-3 activity detection) and cell culture related research, and can be used to treat 1×10? BC-1 PEL cells with 50μM Miltefosine for related experimental research. Additionally, it is used as a fine chemical raw material and pharmaceutical intermediate for the synthesis of related pharmaceutical derivatives, and can be customized according to research and production needs.
Packaging & Storage
Packaging: Laboratory grade: 100mg amber glass bottles or aluminum foil bags with Teflon seals to prevent moisture absorption and light exposure; industrial grade: 1kg/barrel, 100g/aluminum foil bag, 25kg fiber drums with double-layer PE liners, labeled with "Hygroscopic", "Keep Away from Heat" and GHS hazard information (GHS07, H301, H334), as well as hazard codes, risk phrases and safety phrases. Storage: Laboratory grade: Store in a cool, dry, ventilated environment at -20°C; industrial grade: Store in a cool, dry, ventilated warehouse at room temperature below 25°C, relative humidity ≤65%; keep tightly closed to prevent moisture absorption and air contamination; separate from strong acids, bases and oxidizing agents; avoid mixing with toxic and harmful substances; shelf life 24 months under recommended conditions. Transportation: Laboratory grade should be transported with ice packs to maintain low temperature; avoid transportation under high temperature and strong light. Handling: Operate with gloves, goggles, and dust-proof protective clothing; use in ventilated areas to avoid dust inhalation; wash skin thoroughly after contact; if splashed into eyes, rinse with flowing water for 10-15 minutes and seek medical help; if there is a leakage, collect with clean tools and properly dispose of waste; do not ingest; store away from heat sources and open flames.
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