Linagliptin-Shandong Huashang Chemical Co., Ltd.

首页 > Product > Pharmaceutical Chemicals > Linagliptin

Linagliptin

2026-04-14

产品详情

Cas：668270-12-0
产品名称Linagliptin 查看相似产品 >

简介

Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.

Basic Information

Product Name: Linagliptin; Alias: BI 1356, Trajenta, 8-(3-(R)-Aminopiperidin-1-yl)-7-(2-butynyl)-3-methyl-1-(4-methylquinazolin-2-yl)-3,7-dihydro-1H-purine-2,6-dione

CAS Number: 668270-12-0 (MDL: MFCD09991635)

Molecular Formula: C??H??N?O?

Molecular Weight: 472.53 g/mol

Structural Formula: 8-(3-(R)-Aminopiperidin-1-yl)-7-(2-butynyl)-3-methyl-1-(4-methylquinazolin-2-yl)-3,7-dihydro-1H-purine-2,6-dione (a purine derivative with quinazolinyl, aminopiperidinyl and butynyl substituents)

Classification: Dipeptidyl peptidase 4 (DPP-4) inhibitor, pharmaceutical raw material, anti-diabetic drug, small molecule drug, organic heterocyclic compound

Physical & Chemical Properties

Linagliptin is a white to off-white crystalline powder, odorless or with a slight characteristic odor, and has slight hygroscopicity. It is slightly soluble in water, soluble in methanol, ethanol, dimethyl sulfoxide (DMSO) and acetonitrile, and practically insoluble in hexane and ether. Its pH value is 6.5-7.5 (20°C, 0.1g/L in H?O), showing neutrality. It is stable under normal temperature and pressure, but may decompose when exposed to high temperature (above 250°C) or strong oxidants, generating harmful fumes. Its density is 1.38-1.42 g/cm3 (25°C), boiling point is 710.5±70.0°C at 760 mmHg, flash point is 383.5±35.7°C, melting point is 186-190°C, and vapor pressure is <0.0001 mmHg at 25°C with a LogP of 2.8 at 20°C.

Key physical and chemical parameters are detailed in the specification table below, meeting the requirements of high-purity pharmaceutical grade (EP/USP/ChP) and research grade.

Main Uses

Linagliptin is a highly selective dipeptidyl peptidase 4 (DPP-4) inhibitor, mainly used in the treatment of type 2 diabetes mellitus, with wide applications in pharmaceutical and research fields:

Pharmaceutical Industry: Used as an oral anti-diabetic drug for the treatment of type 2 diabetes mellitus. It works by inhibiting DPP-4, prolonging the half-life of endogenous incretin hormones (GLP-1 and GIP), thereby increasing insulin secretion, reducing glucagon secretion, and lowering blood glucose levels. It can be used alone or in combination with other anti-diabetic drugs (such as metformin, sulfonylureas) to improve glycemic control, with low risk of hypoglycemia and weight gain.
Medical Research: Used in preclinical and clinical research on type 2 diabetes mellitus, including the study of DPP-4 inhibitor mechanism of action, drug combination therapy, and long-term safety and efficacy evaluation. It is also used to study the relationship between incretin system and other metabolic diseases (such as obesity, non-alcoholic fatty liver disease).
Pharmaceutical Synthesis: Key raw material for the synthesis of linagliptin pharmaceutical preparations (tablets, capsules). It is used to produce high-purity pharmaceutical formulations that meet international pharmacopoeia standards (EP/USP/ChP), ensuring drug efficacy and safety.
Biochemical Research: Used as a research reagent in biochemical experiments related to DPP-4 enzyme activity, including enzyme inhibition assay, cell signaling pathway research, and in vitro drug screening for type 2 diabetes mellitus.

Packaging & Storage

Packaging Method

Lab/Research Grade: 1g, 5g, 10g, 25g sealed glass bottles or aluminum foil bags (filled with inert gas); 100g, 500g HDPE plastic bottles with PTFE liners, suitable for laboratory research and small-batch testing.

Pharmaceutical Grade: 1kg, 5kg, 25kg/bag (inner PE bag with desiccant, outer three-layer kraft paper bag or polypropylene woven bag); 50kg/100kg galvanized iron drum with PTFE liner and nitrogen-sealed; customized packaging available per customer requirements, complying with GMP standards for pharmaceutical raw materials.

Storage Method

Store in a cool, dry, dark, and well-ventilated warehouse at a temperature of 2-8°C (refrigerated storage recommended). Keep containers tightly sealed and protected from light to prevent moisture absorption, oxidation and discoloration. Avoid contact with water, strong oxidants, strong acids and strong bases; keep away from fire, heat sources, and direct sunlight. It is sensitive to light and humidity, so strict moisture-proof, anti-light and low-temperature measures must be taken. Shelf life is 24 months under standard sealed, low-temperature, and dry storage conditions (complying with GMP storage requirements).

Comprehensive Specification Table

Item	Specification	Unit	Remarks
Product Name	Linagliptin	—	Alias: BI 1356, Trajenta; DPP-4 inhibitor
CAS Number	668270-12-0	—	MDL: MFCD09991635; PubChem: 44611075; RTECS: UY2930000
Molecular Formula	C??H??N?O?	—	Purine derivative; DPP-4 inhibitor with heterocyclic structure
Molecular Weight	472.53	g/mol	Theoretical calculation value; consistent with USP/EP standards
Appearance	White to off-white crystalline powder	—	Odorless or slight characteristic odor; slight hygroscopicity
Purity	≥99.5 (Pharmaceutical Grade); ≥98.0 (Research Grade)	%	Meets USP/EP/ChP standards; high purity for pharmaceutical use
Melting Point	186-190	℃	Literature value; consistent with USP/EP standards; slight decomposition at melting point
Boiling Point	710.5±70.0 (760 mmHg)	℃	Literature value; decomposes before complete boiling
Solubility	Slightly soluble in water; soluble in methanol, DMSO, acetonitrile	—	Practically insoluble in hexane, ether; soluble in polar organic solvents
Density	1.38-1.42 (25°C)	g/cm3	Measured value at room temperature; crystalline solid state
Main Impurities	≤0.2 (Pharmaceutical Grade); ≤1.0 (Research Grade)	%	Including moisture, synthetic intermediates and degradation products
Main Uses	Anti-diabetic drug, pharmaceutical raw material, DPP-4 inhibitor, research reagent	—	Treatment of type 2 diabetes mellitus; pharmaceutical synthesis; medical research
Packaging Method	1g-1kg bottles/bags; 5kg-100kg iron drum/woven bag	—	GMP compliant; sealed, moisture-proof, light-proof; filled with inert gas
Storage Method	2-8°C, cool, dry, dark, sealed; away from moisture/oxidants/acids/bases	—	Shelf life 24 months; GMP storage; avoid light and high temperature

...

联系我们

Shandong Huashang Chemical Co., Ltd.

联系人 Maisey Wang
联系手机+8619031118161
联系电话+8619031-118161-+8616768688388
所在地址No. 57 Industrial South Road,Shandong Province,china

推荐产品