Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Information
Product Name: Aprotinin
Alias: BPTI; Bovine pancreatic trypsin inhibitor; Trasylol; Trypsin inhibitor (basic)
CAS No.: 9087-70-1
EINECS No.: 232-994-9
Molecular Formula: C???H???N??O??S?
Molecular Weight: 6511.44 g/mol
Classification: Biochemical reagent; Serine protease inhibitor; Polypeptide drug; Enzyme inhibitor
Physical & Chemical Properties
Appearance: White to off-white lyophilized powder or crystalline solid
Solubility: Freely soluble in water (>10 mg/mL) and aqueous buffers; insoluble in ethanol, acetone, ether
Stability: Heat and acid stable; stable at pH 1–12; avoid repeated freeze-thaw cycles
Isoelectric Point (pI): 10.5
Storage: 2–8°C, dry, dark, sealed storage
Specification Table
| Item | Specification | Unit | Remarks |
| Product Name | Aprotinin | — | Bovine pancreatic trypsin inhibitor |
| CAS Number | 9087-70-1 | — | Polypeptide protease inhibitor |
| Appearance | White to off-white powder/crystalline solid | — | Lyophilized or crystal form |
| Molecular Formula | C???H???N??O??S? | — | 58 amino acids, 3 disulfide bonds |
| Molecular Weight | 6511.44 | g/mol | — |
| Purity | ≥95 | % | Gel filtration chromatography |
| Specific Activity | ≥5500 KIU/mg | KIU/mg | Dry weight |
Main Uses
- Clinical Hemostasis: Antifibrinolytic agent for cardiac surgery (CABG), liver transplantation, reducing transfusion needs by 30%–50%
- Acute Pancreatitis: Inhibits trypsin/chymotrypsin activation, prevents pancreatic autodigestion
- Biochemical Research: Protease inhibitor to protect proteins from degradation in Western blotting, enzyme assays
- Anti-inflammatory & Antishock: Inhibits kallikrein, reduces bradykinin production, mitigates inflammation
- Postoperative Adhesion Prevention: Local application reduces fibrin deposition and abdominal/pleural adhesions
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