Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Information
Product Name: Nepafenac
Alias: 2-Amino-3-benzoylbenzeneacetamide; Nevanac; AL 6515; AHR 9434
CAS No.：78281-72-8
EINECS No.：200-001-8
Molecular Formula：C??H??N?O?
Molecular Weight：254.28 g/mol
MDL Number：MFCD08067732
Classification：Nonsteroidal Anti-Inflammatory Drug (NSAID); COX-1/COX-2 inhibitor; Ophthalmic anti-inflammatory agent; Prodrug of amfenac
Physical & Chemical Properties
Appearance: Yellow or pale yellow crystalline powder
Melting Point: 177–181 °C
Boiling Point: 562.5 ± 50.0 °C (Predicted)
Density: 1.249 ± 0.06 g/cm3 (Predicted)
Flash Point: 294.0 ± 30.1 °C
Solubility: Insoluble in water; soluble in DMSO (≥5 mg/mL), DMF; slightly soluble in ethanol
Stability: Stable at room temperature; heat-sensitive; store refrigerated (0–10 °C), sealed, dry and away from light
Structure
Specification Table
| Item | Specification | Unit | Remarks |
| Product Name | Nepafenac | — | 2-Amino-3-benzoylbenzeneacetamide |
| CAS Number | 78281-72-8 | — | Ophthalmic API |
| Appearance | Yellow or pale yellow crystalline powder | — | Odorless |
| Molecular Formula | C??H??N?O? | — | Prodrug structure |
| Molecular Weight | 254.28 | g/mol | — |
| Melting Point | 177–181 | ℃ | Lit. |
| Purity | ≥98.0 | % | HPLC |
| Storage Condition | 0–10 °C, sealed, dry | — | Heat-sensitive |
Main Uses
- Ophthalmic NSAID: Topical eye drops (0.1% Nevanac, 0.3% Ilevro) for treating postoperative pain and inflammation after cataract surgery。
- COX Inhibitor: Prodrug converted to amfenac by ocular hydrolases; inhibits cyclooxygenase (COX-1/COX-2) to reduce prostaglandin synthesis。
- Diabetic Macular Edema: Reduces risk of postoperative macular edema in diabetic patients undergoing cataract surgery。
- Pharmaceutical Intermediate: Key raw material for anti-inflammatory and analgesic drug synthesis; research tool for inflammation and pain mechanism studies。
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