Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Information
Product Name: Cetilistat
Alias: ATL-962; 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one
CAS No. : 282526-98-1
Molecular Formula: C??H??NO?
Molecular Weight: 401.58 g/mol
Classification: Anti-obesity API; Pancreatic lipase inhibitor; Gastrointestinal lipase inhibitor
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Melting Point: ~68–70 °C
- Solubility: Insoluble in water; soluble in methanol, DMSO, acetonitrile (slightly)
- Stability: Stable under dry & ambient conditions; light-sensitive, store sealed & dark
- IC50 (Human pancreatic lipase): 5.95 nM (potent inhibitor)
Specification Table
| Item | Specification | Unit | Remarks |
| Product Name | Cetilistat | — | Anti-obesity API |
| CAS No. | 282526-98-1 | — | Pharma grade |
| Appearance | White crystalline powder | — | Fine powder |
| Molecular Formula | C??H??NO? | — | Benzoxazinone derivative |
| Molecular Weight | 401.58 | g/mol | — |
| Purity | ≥98.0 | % | HPLC |
| Moisture | ≤0.5 | % | Karl Fischer |
| Melting Point | 68–70 | °C | — |
Main Uses
- Anti-obesity drug (API) — Potent, selective gastrointestinal/pancreatic lipase inhibitor; blocks triglyceride breakdown → reduces fat absorption → weight management.
- Hyperlipidemia treatment — Lowers serum triglycerides; for mixed hyperlipidemia & obesity-related metabolic disorders.
- Diabetes + obesity — Approved in Japan (2013, brand Oblean); Phase III in US; suitable for diabetic & non-diabetic obese patients.
- Research reagent — Tool for lipase study, obesity & metabolic syndrome research; impurity reference standard.
Mechanism of Action
- Covalently binds active serine site of gastric/pancreatic lipases → enzyme deactivation.
- Triglycerides not hydrolyzed → unabsorbed, excreted in feces → reduced calorie intake & body weight.
Packaging & Storage
- Packaging: 1g/5g/25g/100g foil bag; 1kg aluminum can
- Storage: 2–8 °C; sealed, dry, dark; away from moisture/strong light
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