Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Information
Product Name: Palonosetron hydrochloride
Alias: Palonosetron HCl; (3aS)-2-[(S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride
CAS No.: 135729-62-3
Molecular Formula: C??H??ClN?O
Molecular Weight: 332.87
Classification: Antiemetic; 5-HT3 receptor antagonist; Pharmaceutical API
Physical & Chemical Properties
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: >290°C
Specific Rotation: [α]D2? -90° to -110° (c=0.4 in water)
Solubility: Freely soluble in water; soluble in propylene glycol; slightly soluble in ethanol, methanol
Stability: Heat-sensitive; store at -20°C under inert atmosphere; avoid strong light and high temperature
Specification Table
| Item | Specification | Unit | Remarks |
| Product Name | Palonosetron hydrochloride | — | Anti-emetic API |
| CAS No. | 135729-62-3 | — | Pharma grade |
| Appearance | White to off-white crystalline powder | — | High purity |
| Molecular Formula | C19H25ClN2O | — | Single isomer |
| Molecular Weight | 332.87 | g/mol | — |
| Purity | ≥98.0 | % | HPLC |
| Water Content | ≤0.5 | % | Karl Fischer |
Main Uses
- Highly selective 5-HT3 receptor antagonist for prevention/treatment of chemotherapy-induced nausea and vomiting (CINV) (acute and delayed).
- Prevention of postoperative nausea and vomiting (PONV).
- Longer half-life (~40 h) than other 5-HT3 antagonists; fewer side effects (headache, constipation <10%).
- Used alone or combined with netupitant for enhanced antiemetic efficacy.
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