Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Information
Product Name: Trimethylsilyl trifluoromethanesulfonate
Alias: TMSOTf; Trimethylsilyl triflate
CAS No: 27607-77-8
Molecular Formula: C4H9F3O3SSi
Molecular Weight: 222.09
Classification: Organosilicon reagent; Strong Lewis acid; Silylation reagent; Catalyst
Physical & Chemical Properties
Appearance: Colorless clear liquid
Odor: Irritating odor
Boiling Point: 78-80 °C at 15 mmHg
Density: 1.22 g/mL (25 °C)
Solubility: Miscible with dichloromethane, chloroform, ether, toluene; Reacts violently with water
Stability: Moisture sensitive; Corrosive; Incompatible with water, alcohol, strong base; Store under inert gas, sealed and dry
Specification Table
| Item | Specification | Unit | Remarks |
| Product Name | Trimethylsilyl trifluoromethanesulfonate | — | Organic silicon catalyst |
| CAS No | 27607-77-8 | — | Synthetic grade |
| Appearance | Colorless transparent liquid | — | Low viscosity liquid |
| Molecular Formula | C4H9F3O3SSi | — | Fluorosulfonate silane |
| Molecular Weight | 222.09 | g/mol | — |
| Purity | ≥99.0 | % | GC |
Main Uses
- Powerful silylation agent and Lewis acid catalyst for organic synthesis.
- Widely used in glycosylation, cyclization, condensation and coupling reactions.
- Protecting group reagent for hydroxyl, carboxyl and amine groups in pharmaceutical synthesis.
- Applied in the preparation of fine chemicals, nucleoside intermediates and natural product total synthesis.
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