Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Pregnenolone
CAS Number: 145-13-1
Alias: 3β-Hydroxypregn-5-en-20-one, Pregnolon
Molecular Formula: C21H32O2
Molecular Weight: 328.48 g/mol
Structural Information
- Structure Type: Natural steroid compound, an important intermediate in steroid hormone biosynthesis.
- Structural Features: Possesses a typical four-ring steroid skeleton, containing one hydroxyl group and one ketone group. It has multiple chiral carbon atoms and stable cyclic structure, showing good lipophilicity and biological activity.
Physical & Chemical Properties
- Appearance: White or off-white crystalline powder
- Odor: Odorless
- Melting Point: 187 - 193 °C
- Specific Rotation: +27° ~ +32° (c=1, ethanol)
- Solubility: Soluble in ethanol, methanol, chloroform, ether and vegetable oil; slightly soluble in hot petroleum ether; practically insoluble in water
- Stability: Stable under dry, sealed and dark conditions. Gradually oxidized and deteriorated under long-term exposure to strong light, high temperature and air. Keep away from strong oxidants.
Synthesis & Applications
Synthesis Method
It can be extracted from animal adrenal glands and other biological tissues. Industrial production is mainly based on diosgenin or cholesterol as raw materials, through multi-step chemical reactions such as ring opening, oxidation, reduction and structural transformation, then refined by recrystallization to obtain high-purity products.
Main Applications
- Pharmaceutical industry: Key steroid intermediate, widely used for the synthesis of progesterone, estrogen, corticosteroids and other steroid drugs.
- Biochemical research: Applied in the study of hormone metabolism and endocrine related experiments.
- Health products: Used as raw material for functional supplements to regulate human endocrine and nervous system.
- Laboratory reagent: Standard substance and analytical reagent for steroid analysis and testing.
Safety & Storage Instructions
- Hazard Classification: Low toxicity, mild irritant
- Personal Protection: Wear chemical resistant gloves and dust mask during operation. Avoid inhalation of dust and direct contact with skin, eyes and mucous membranes.
- Storage Condition: Store in tightly sealed containers. Keep in cool, dry, dark and well-ventilated environment. Keep away from heat sources, direct sunlight and oxidizing substances.
- Transportation: Classified as general fine chemical. No dangerous goods transport restrictions. Prevent package damage, dampness and light exposure during transportation.
Quality & Spectral Data
- Purity (HPLC): ≥99.0%
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Related Substances: Total impurities ≤1.0%
- 1H NMR Spectrum: Consistent with standard reference spectrum
- IR Spectrum: Characteristic absorption peaks conform to the standard structure
Information Summary Table
| Item | Specification |
| CAS Number | 145-13-1 |
| Product Name | Pregnenolone |
| Synonym | 3β-Hydroxypregn-5-en-20-one, Pregnolon |
| Molecular Formula | C21H32O2 |
| Molecular Weight | 328.48 g/mol |
| Appearance | White or off-white crystalline powder, odorless |
| Melting Point | 187-193 °C |
| Specific Rotation | +27° ~ +32° (in ethanol) |
| Solubility | Soluble in alcohols, chloroform, ether; insoluble in water |
| Purity | ≥99.0% (HPLC) |
| Storage Condition | Sealed, cool, dry and dark place, away from light and oxidants |
| Hazard Property | Low toxicity, mild irritant, general chemical |
| Main Usage | Steroid pharmaceutical intermediate, biochemical reagent, health care raw material |
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