Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: 4-Nitrophthalimide
CAS Number: 89-40-7
Alias: 4-Nitro-1,2-benzenedicarboximide
Molecular Formula: C8H4N2O4
Molecular Weight: 192.13 g/mol
IUPAC Name: 4-nitroisoindole-1,3-dione
Structural Information
- Structure Type: Aromatic imide compound, phthalimide derivative
- Structural Features: Contains a benzene ring fused with five-membered imide ring, and a nitro group attached at the 4-position. The electron-withdrawing nitro group enhances molecular reactivity for further substitution and synthesis.
Physical & Chemical Properties
- Appearance: Pale yellow to yellow crystalline powder
- Odor: Odorless
- Melting Point: 204–206 °C
- Solubility: Practically insoluble in water; slightly soluble in ethanol, methanol; soluble in DMF, DMSO and hot organic solvents
- Stability: Stable under normal temperature and sealed conditions. Avoid strong light, high temperature, strong oxidants and strong alkalis; prone to hydrolysis under alkaline environment.
Synthesis & Applications
Synthesis Method
Prepared by nitration of phthalimide under mixed acid catalysis. The crude product is filtered, washed and recrystallized to obtain high-purity product.
Main Applications
- Pharmaceutical Intermediates: Key raw material for synthesizing antibacterial drugs, anti-inflammatory agents and heterocyclic medicines.
- Dye & Pigment Industry: Intermediate for manufacturing organic dyes, fluorescent pigments and colorants.
- Organic Synthesis: Widely used for the preparation of amine compounds and other fine chemical derivatives.
- Chemical Research: Standard reagent for organic synthesis and material science research.
Safety & Storage Instructions
- Hazard Classification: Moderate irritant; irritates skin, eyes and respiratory tract
- Personal Protection: Wear dust mask, safety goggles and chemical resistant gloves. Avoid inhalation of dust and direct body contact.
- Storage Condition: Keep containers tightly sealed. Store in cool, dry, dark and well-ventilated area. Keep away from heat sources, oxidants and alkaline substances.
- Transportation: Classified as general chemicals. Prevent package damage, moisture and long-term sunlight exposure during transit.
Quality & Spectral Data
- Purity (HPLC): ≥99.0%
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Melting Range: 204–206 °C
- IR Spectrum: Characteristic absorption peaks conform to standard reference spectrum
Information Summary Table
| Item | Specification |
| CAS Number | 89-40-7 |
| Product Name | 4-Nitrophthalimide |
| Synonym | 4-Nitro-1,2-benzenedicarboximide |
| Molecular Formula | C8H4N2O4 |
| Molecular Weight | 192.13 g/mol |
| Appearance | Yellow crystalline powder |
| Melting Point | 204–206 °C |
| Solubility | Insoluble in water; soluble in DMF, DMSO |
| Purity | ≥99.0% (HPLC) |
| Storage Condition | Sealed, cool dry dark place, away from oxidants and alkalis |
| Hazard Property | Moderate irritant |
| Main Usage | Pharmaceutical intermediate, dye intermediate, organic synthesis raw material |
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