Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
CAS Number: 89-25-8
Alias: Edaravone; 3-Methyl-1-phenyl-2-pyrazolin-5-one; MPP
Molecular Formula: C10H10N2O
Molecular Weight: 174.20
IUPAC Name: 5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
Structural Information
- Structure Type: Pyrazolone heterocyclic compound
- Structural Features: Pyrazole five-membered nitrogen heterocycle, with methyl at 5-position, phenyl at 2-position, carbonyl group at 3-position; exists in tautomeric form, strong antioxidant activity
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Melting Point: 127–129 °C
- Solubility: Slightly soluble in water; soluble in ethanol, methanol, DMSO, alkaline aqueous solution
- Stability: Stable under dry dark storage; sensitive to strong light and high temperature; reacts with oxidants to form colored derivatives
Synthesis & Applications
Production Method
Condensation of ethyl acetoacetate with phenylhydrazine under acidic catalysis, then recrystallization purification.
Main Applications
- Pharmaceutical API: Edaravone, clinical antioxidant drug for cerebral infarction, nerve injury protection
- Analytical reagent: Color developing agent for metal ion spectrophotometric detection
- Fine chemical intermediate: Raw material for synthetic dyes and photographic chemicals
- Antioxidant raw material: Stabilizer for polymer materials
Safety & Storage Instructions
- Hazard Classification: Mild irritant to skin and eyes
- Personal Protection: Dust mask and nitrile gloves during powder operation
- Storage Condition: Hermetically sealed, cool dark dry warehouse, light-proof
- Transportation: General industrial chemical, avoid sunlight and dampness
Quality Specifications
- Purity: ≥99.0% (HPLC)
- Loss on Drying: ≤0.3%
- Single unknown impurity: ≤0.1%
- Total impurities: ≤0.5%
Information Summary Table
| Item | Specification |
| CAS Number | 89-25-8 |
| Product Name | 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one |
| Synonym | Edaravone, MPP |
| Molecular Formula | C10H10N2O |
| Molecular Weight | 174.20 |
| Appearance | White crystalline powder |
| Melting Point | 127–129 °C |
| Solubility | Soluble in alcohols and alkali water, slightly soluble in water |
| Purity Standard | ≥99.0% |
| Storage Condition | Sealed cool dark place, light-proof |
| Hazard Property | Mild skin & eye irritant |
| Main Usage | Cerebroprotective API, metal color reagent, dye intermediate |
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