Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Vardenafil hydrochloride
CAS Number: 224785-91-5
Alias: Levitra hydrochloride
Molecular Formula: C23H33ClN6O4S
Molecular Weight: 525.06
IUPAC Name: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine hydrochloride
Structural Information
- Structure Type: Imidazotriazine heterocyclic hydrochloride salt, selective PDE5 inhibitor
- Structural Features: Fused imidazo-triazine ring structure, ethoxy phenyl sulfonyl piperazine side chain, exists as stable hydrochloride salt, high target receptor selectivity
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Melting Point: Decomposes above 210 °C
- Specific Rotation: Optical inactive racemic compound
- Solubility: Soluble in water, methanol, dilute acid; sparingly soluble in ethanol; insoluble in ether, alkanes
- Stability: Stable under dry, light-proof sealed storage; hydrolyzes under strong alkaline high temperature; incompatible with strong oxidants
Synthesis & Applications
Production Method
Multi-step heterocyclic synthesis: cyclization to form imidazotriazine core, aromatic sulfonylation with substituted phenyl sulfonyl chloride, piperazine coupling, salt formation with hydrochloric acid, recrystallization purification.
Main Applications
- Pharmaceutical API: Oral PDE5 inhibitor drug for the treatment of male erectile dysfunction
- Biochemical Research Reagent: Selective phosphodiesterase 5 inhibitor for cell and molecular mechanism study
Safety & Storage Instructions
- Hazard Classification: Mild irritant to skin, eyes and respiratory tract
- Personal Protection: Dust respirator, chemical goggles, nitrile gloves during powder operation
- Storage Condition: Hermetically sealed, low-temperature dark dry warehouse, strictly light-proof and moisture-proof
- Transportation: Class 9 general hazardous chemicals, avoid sunlight, dampness and package breakage
Quality Specifications
- Purity: ≥99.0% (HPLC)
- Loss on Drying: ≤0.4%
- Residue on Ignition: ≤0.1%
- Single maximum unknown impurity: ≤0.10%
- Total related impurities: ≤0.50%
Information Summary Table
| Item | Specification |
| CAS Number | 224785-91-5 |
| Product Name | Vardenafil hydrochloride |
| Synonym | Levitra hydrochloride |
| Molecular Formula | C23H33ClN6O4S |
| Molecular Weight | 525.06 |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in water and methanol, insoluble in ether |
| Purity Standard | ≥99.0% |
| Storage Condition | Sealed cool dark dry warehouse, light & moisture resistant |
| Hazard Property | Mild skin, eye and respiratory irritant |
| Main Usage | Erectile dysfunction treatment API, PDE5 research inhibitor |
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