Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: (R)-2-(tert-butoxycarbonylamino)-2,3-dimethylbutanoic acid
CAS Number: 53940-90-2
Alias: Boc-D-Tle-OH; N-Boc-D-tert-leucine
Molecular Formula: C11H21NO4
Molecular Weight: 231.29
IUPAC Name: (2R)-2-[(tert-butoxy)carbonyl]amino-2,3-dimethylbutanoic acid
Structural Information
- Structure Type: Chiral protected amino acid derivative, Boc-protected D-tert-leucine
- Structural Features: Chiral carbon center at C2, tert-butoxycarbonyl (Boc) protecting group on amino group, bulky isopropyl substituent, carboxylic acid terminal group
Physical & Chemical Properties
- Appearance: White crystalline powder
- Odor: Odorless
- Melting Point: 72–76 °C
- Specific Rotation: [α]20/D -10° ~ -14° (c=1, MeOH)
- Solubility: Soluble in DCM, THF, methanol, ethanol; slightly soluble in water; insoluble in alkane solvents
- Stability: Stable under dry low-temperature light-proof storage; Boc group deprotects under strong acid; sensitive to high temperature and strong alkali
Synthesis & Applications
Production Method
D-tert-leucine reacts with di-tert-butyl dicarbonate under weak alkaline catalysis, purified by recrystallization.
Main Applications
- Peptide synthesis raw material: Chiral building block for synthetic peptide drugs
- Pharmaceutical intermediate: Key fragment for small-molecule chiral APIs
- Organic synthesis reagent: Chiral ligand precursor for asymmetric catalysis
Safety & Storage Instructions
- Hazard Classification: Mild irritant to skin and eyes
- Personal Protection: Dust mask, nitrile gloves, chemical goggles for powder operation
- Storage Condition: Hermetically sealed, 2–8 °C cool dark dry warehouse, moisture-proof
- Transportation: General fine chemical, avoid high temperature and sunlight exposure
Quality Specifications
- Purity: ≥99.0% (HPLC)
- Chiral Purity (ee): ≥99.5%
- Loss on Drying: ≤0.3%
- Single unknown impurity: ≤0.1%
Information Summary Table
| Item | Specification |
| CAS Number | 53940-90-2 |
| Product Name | (R)-2-(tert-butoxycarbonylamino)-2,3-dimethylbutanoic acid |
| Synonym | Boc-D-Tle-OH, N-Boc-D-tert-leucine |
| Molecular Formula | C11H21NO4 |
| Molecular Weight | 231.29 |
| Appearance | White crystalline powder |
| Melting Point | 72–76 °C |
| Solubility | Soluble in organic solvents, slightly soluble in water |
| Purity Standard | ≥99.0%, ee ≥99.5% |
| Storage Condition | Sealed, 2–8°C light & moisture resistant storage |
| Hazard Property | Mild skin & eye irritant |
| Main Usage | Chiral peptide building block, pharmaceutical chiral intermediate |
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