Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Theophylline
CAS Number: 58-55-9
Alias: 1,3-Dimethylxanthine
Molecular Formula: C7H8N4O2
Molecular Weight: 180.16
IUPAC Name: 1,3-dimethyl-7H-purine-2,6-dione
Structural Information
- Structure Type: Purine alkaloid methylxanthine compound
- Structural Features: Purine bicyclic heterocycle with two methyl substituents on nitrogen atoms, two carbonyl groups, weak acidic active hydrogen on N7
Physical & Chemical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slightly bitter taste
- Melting Point: 270–274 °C (sublimation)
- Solubility: Slightly soluble in cold water, soluble in hot water, ethanol, dilute acid and alkaline solution; insoluble in ether, chloroform
- Stability: Stable under normal sealed storage; forms soluble salts with alkali; resistant to weak acid, decomposes under strong concentrated acid heating
Synthesis & Applications
Production Method
Uric acid methylation and cyclization, then purification by recrystallization; or synthesized from caffeine demethylation.
Main Applications
- Pharmaceutical API: Bronchodilator, used for asthma, chronic obstructive pulmonary disease treatment; also diuretic and cardiac stimulant raw material
- Biochemical reagent: Standard reference substance for purine derivative testing
- Feed additive: Improve animal respiratory health auxiliary raw material
Safety & Storage Instructions
- Hazard Classification: Mild irritant to skin and eyes; excessive intake causes nervous excitement
- Personal Protection: Dust mask and nitrile gloves during powder handling
- Storage Condition: Hermetically sealed, cool dry ventilated warehouse, moisture-proof
- Transportation: General pharmaceutical raw material, avoid damp and extrusion
Quality Specifications
- Purity: ≥99.0% (HPLC)
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Heavy Metal (Pb): ≤10 ppm
Information Summary Table
| Item | Specification |
| CAS Number | 58-55-9 |
| Product Name | Theophylline |
| Synonym | 1,3-Dimethylxanthine |
| Molecular Formula | C7H8N4O2 |
| Molecular Weight | 180.16 |
| Appearance | White crystalline powder |
| Melting Point | 270–274 °C |
| Solubility | Soluble in hot water, dilute acid and alkali |
| Purity Standard | ≥99.0% |
| Storage Condition | Sealed cool dry warehouse, moisture-proof |
| Hazard Property | Mild skin & eye irritant, central nervous stimulant in overdose |
| Main Usage | Respiratory treatment API, biochemical standard reagent |
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