Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Tianeptine
CAS Number: 66981-73-5
Alias: Tianeptine free acid, 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide, Coaxil
Molecular Formula: C21H25ClN2O4S
Molecular Weight: 436.95
IUPAC Name: 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
Structural Information
- Structure Type: Tricyclic sultam heterocyclic antidepressant, amphoteric carboxylic acid
- Structural Features: Fused dibenzothiazepine seven-membered ring with sulfonyl group, chlorine substituent, methyl nitrogen, long alkyl carboxylic acid side chain; dual acid-base dissociation property
Physical & Chemical Properties
- Appearance: White to off-white crystalline solid
- Odor: Odorless
- Melting Point: 129–131 °C
- Density: 1.38 g/cm3
- Boiling Point: 609.2 °C (760 mmHg)
- Flash Point: 322.2 °C
- Solubility: Freely soluble in water, methanol, dichloromethane; soluble in ethanol; slightly soluble in alkane solvents
- Stability: Hygroscopic; stable under inert low-temperature (-20°C) sealed storage; prone to discoloration under long-term high temperature and strong light; reacts with alkali to form soluble sodium salt
Synthesis & Applications
Production Method
Multi-step cyclization to construct dibenzothiazepine core skeleton, side chain alkylamination, carboxylation, then recrystallization purification.
Main Applications
- Pharmaceutical API: Atypical tricyclic antidepressant raw material, treats major depressive disorder, anxiety-depression syndrome, alcohol withdrawal emotional disorders
- Biochemical research reagent: Selective 5-HT transporter modulator for neuroscience mechanism study
- Pharmaceutical intermediate: Precursor for tianeptine sodium salt formulation raw material
Safety & Storage Instructions
Hazard Classification (UN 3249, Class 6.1 Toxic substance, Packing Group III)
- H302 Harmful if swallowed
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
Personal Protection
Chemical splash goggles, nitrile solvent-resistant gloves, dust respirator; operate in fully ventilated workshop
Storage Condition
Hermetically sealed nitrogen-filled container, -20°C cold warehouse, light-proof and strictly moisture-proof; separate from strong oxidants and strong bases
Transportation
Toxic category hazardous goods; avoid sunlight, dampness, package breakage and violent collision
Quality Specifications
- Purity: ≥99.0% (HPLC)
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Single unknown impurity: ≤0.10%
- Total related impurities: ≤0.50%
Information Summary Table
| Item | Specification |
| CAS Number | 66981-73-5 |
| Product Name | Tianeptine |
| Synonym | Tianeptine free acid |
| Molecular Formula | C21H25ClN2O4S |
| Molecular Weight | 436.95 |
| Appearance | White crystalline solid |
| Melting Point | 129–131 °C |
| Solubility | Soluble in water, methanol, DCM |
| Purity Standard | ≥99.0% |
| Storage Condition | Sealed nitrogen-filled, -20°C light & moisture resistant storage |
| Hazard Property | Toxic oral, irritant to skin, eyes and respiratory tract |
| Main Usage | Antidepressant API, neuroscience research reagent |
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