Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Eplerenone
CAS Number: 107724-20-9
Alias: Inspra, CGP 30083, Epoxymexrenone
Molecular Formula: C24H30O6
Molecular Weight: 414.49
IUPAC Name: (7α,11α,17α)-9,11-epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
Structural Information
- Structure Type: Selective steroid mineralocorticoid receptor antagonist
- Structural Features: Pregnane steroid four-ring skeleton, 9α,11α-epoxy bridge, 7α-methyl carboxylate, 17-position γ-lactone ring; high selectivity for aldosterone receptor, low affinity to androgen/progesterone receptors
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder, odorless
- Melting Point: 241–243 °C
- Specific Rotation: [α]20/D +5° (c=0.437, chloroform)
- Density: 1.31 g/cm3
- Solubility: Very slightly soluble in water; soluble in DMSO, methanol, ethanol; insoluble in alkane solvents
- Stability: Non-hygroscopic; stable under dry, light-proof sealed storage; stable in neutral/weak acid; prone to ester hydrolysis under strong alkaline heating
Synthesis & Applications
Production Method
Multi-step chiral steroid synthesis: construct pregnane core, epoxy cyclization, carboxylation, lactonization, methyl esterification, refined by recrystallization.
Main Applications
- Pharmaceutical API: Selective aldosterone antagonist, oral anti-hypertensive drug; treats hypertension, post-myocardial infarction congestive heart failure
- Biochemical reagent: Research tool for mineralocorticoid receptor signaling mechanism study
- Pharmaceutical intermediate: Raw material for cardiovascular drug analog synthesis
Safety & Storage Instructions
- Hazard Classification: Mild irritant to skin and eyes
- Personal Protection: Dust mask, nitrile gloves, chemical goggles during powder operation
- Storage Condition: Hermetically sealed container, 2–8 °C cool dark warehouse, light-proof; long-term storage at -20 °C
- Transportation: General fine chemical, avoid high temperature, sunlight and dampness
Quality Specifications
- Purity: ≥99.0% (HPLC)
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Single maximum unknown impurity: ≤0.10%
- Total related impurities: ≤0.50%
Information Summary Table
| Item | Specification |
| CAS Number | 107724-20-9 |
| Product Name | Eplerenone |
| Synonym | Inspra, CGP 30083 |
| Molecular Formula | C24H30O6 |
| Molecular Weight | 414.49 |
| Appearance | White crystalline powder |
| Melting Point | 241–243 °C |
| Solubility | Soluble in DMSO/methanol, slightly soluble in water |
| Purity Standard | ≥99.0% |
| Storage Condition | Sealed, 2–8°C light & moisture resistant storage |
| Hazard Property | Mild skin & eye irritant |
| Main Usage | Antihypertensive & heart failure treatment API, steroid receptor research reagent |
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