Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Triphenylmethyl chloride
CAS Number: 76-83-5
Alias: Trityl chloride, Chlorotriphenylmethane
Molecular Formula: C19H15Cl
Molecular Weight: 278.78
IUPAC Name: (chloromethanetriyl)tribenzene
Structural Information
- Structure Type: Aromatic alkyl halide protecting group reagent
- Structural Features: Central carbon atom connected with three benzene rings and one chlorine atom; trityl carbocation has high stability, easily undergoes nucleophilic substitution to protect hydroxyl, amino and thiol groups
Physical & Chemical Properties
- Appearance: White to pale yellow crystalline solid
- Odor: Pungent irritating odor
- Melting Point: 110–113 °C
- Boiling Point: Decomposes before boiling
- Solubility: Insoluble in water; soluble in dichloromethane, THF, toluene, benzene; slightly soluble in ethanol
- Stability: Extremely sensitive to moisture, hydrolyzes rapidly in humid air to triphenylmethanol and hydrogen chloride; incompatible with water, alcohols, amines, strong nucleophiles; stable under anhydrous inert low-temperature sealed storage
Synthesis & Applications
Production Method
Triphenylmethane undergoes chlorination reaction with chlorine or thionyl chloride, purified by recrystallization under anhydrous environment.
Main Applications
- Organic synthesis protecting reagent: Trityl protective agent for -OH, -NH2, -SH in peptide, carbohydrate and drug intermediate synthesis
- Catalyst auxiliary: Precursor for triphenylmethyl carbocation catalyst
- Chemical analysis reagent: Derivatization reagent for polar compound chromatographic detection
Safety & Storage Instructions
GHS Hazard Classification
- H314 Causes severe skin burns and eye damage
- H335 May cause respiratory irritation
- Hydrolyzes to release corrosive HCl gas
Personal Protection
Full-face splash goggles, acid-resistant protective clothing, butyl nitrile gloves, organic vapor respirator; all operations carried out in anhydrous fume hood, strictly isolate water vapor
Storage Condition
Hermetically sealed nitrogen-filled container, cool dry anhydrous warehouse (≤20°C); completely isolated from water, alcohols, amines, oxidants
Transportation
Class 8 corrosive hazardous chemicals; waterproof packaging, avoid damp environment, violent collision and high temperature exposure
Quality Specifications
- Purity: ≥99.0% (HPLC/GC)
- Loss on Drying: ≤0.2%
- Free triphenylmethanol impurity: ≤0.1%
Information Summary Table
| Item | Specification |
| CAS Number | 76-83-5 |
| Product Name | Triphenylmethyl chloride |
| Synonym | Trityl chloride, Chlorotriphenylmethane |
| Molecular Formula | C19H15Cl |
| Molecular Weight | 278.78 |
| Appearance | White light yellow crystalline solid |
| Melting Point | 110–113 °C |
| Solubility | Soluble in anhydrous organic solvents, hydrolyze in water |
| Purity Standard | ≥99.0% |
| Storage Condition | Sealed nitrogen-filled anhydrous cool storage, isolate moisture |
| Hazard Property | Corrosive, releases HCl when damp, severe skin & eye burn hazard |
| Main Usage | Hydroxyl/amino/thiol protecting reagent for pharmaceutical & peptide synthesis |
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