Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Prilocaine
CAS Number: 721-50-6
Alias: Propitocaine, 2-(Propylamino)-o-propionotoluidide
Molecular Formula: C13H20N2O
Molecular Weight: 220.31
IUPAC Name: N-(2-methylphenyl)-2-(propylamino)propanamide
Structural Information
- Structure Type: Amide-type amino local anesthetic
- Structural Features: Toluene parent structure connected with propanamide and propylamino groups; weak vasodilatory effect, low cardiac toxicity, metabolized via liver amidase, less methemoglobinemia risk at clinical routine dosage
Physical & Chemical Properties
- Appearance: White crystalline powder
- Odor: Odorless
- Melting Point: 37–38 °C
- Boiling Point: Distills under reduced pressure, decomposes at high temperature
- Solubility: Slightly soluble in water; soluble in ethanol, methanol, chloroform, acetone, dilute acid; insoluble in alkane solvents
- Stability: Stable under dry sealed storage; stable in weak acid/neutral medium; easy hydrolysis under strong alkaline heating; light stable, non-hygroscopic
Synthesis & Applications
Production Method
2-Methylaniline reacts with 2-bromopropionic acid to form amide intermediate, then alkylation with propylamine, refined by recrystallization.
Main Applications
- Pharmaceutical API: Local anesthetic for infiltration anesthesia, nerve block, epidural anesthesia; often compounded with lidocaine
- Medical preparation raw material: Raw material for topical anesthetic cream, injection formulations
- Anesthesiology research reagent: Comparative test compound for local anesthetic pharmacology
Safety & Storage Instructions
GHS Hazard Classification
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
Personal Protection
Dust mask, chemical splash goggles, nitrile gloves; operate in ventilated fume hood
Storage Condition
Hermetically sealed container, cool dark dry warehouse; isolate strong alkaline substances
Transportation
General pharmaceutical intermediate solid; avoid high temperature, direct sunlight and dampness
Quality Specifications
- Purity: ≥99.0% (HPLC)
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Single unknown impurity: ≤0.10%
Information Summary Table
| Item | Specification |
| CAS Number | 721-50-6 |
| Product Name | Prilocaine |
| Synonym | Propitocaine |
| Molecular Formula | C13H20N2O |
| Molecular Weight | 220.31 |
| Appearance | White crystalline powder |
| Melting Point | 37–38°C |
| Solubility | Slightly soluble in water, soluble in alcohols & chloroform |
| Purity Standard | ≥99.0% |
| Storage Condition | Sealed cool dark storage, away from strong alkali |
| Hazard Property | Mild irritant to skin, eyes and respiratory tract |
| Main Usage | Local anesthetic raw material, injection/topical anesthetic formulation intermediate |
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