Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Choline glycerophosphate
CAS Number: 28319-77-9
Alias: L-α-Glycerylphosphorylcholine, Alpha-GPC, Choline Alfoscerate, GPC, sn-Glycero-3-phosphocholine
Molecular Formula: C8H20NO6P
Molecular Weight: 257.22
IUPAC Name: (2R)-2,3-dihydroxypropyl 2-(trimethylammonio)ethyl phosphate
Structural Information
- Structure Type: Water-soluble zwitterionic phospholipid metabolite, natural choline precursor
- Structural Features: Glycerol backbone linked with phosphate and quaternary ammonium choline group; no fatty acid side chains, strong hydrophilicity; carries both positive trimethylammonium cation and negative phosphate anion, easily penetrates blood-brain barrier to supply choline for brain tissue
Physical & Chemical Properties
- Appearance: White to off-white hygroscopic crystalline powder / viscous concentrated aqueous liquid
- Odor: Odorless, slight mild sweet taste
- Melting Point: 142.5–143 °C
- Specific Rotation: [α]D2? -2.7° (c=2.7, water, pH 2.5)
- Boiling Point: Decomposes above 480 °C under normal pressure
- Solubility: Freely soluble in water, methanol, ethanol; slightly soluble in DMSO under heating; insoluble in ethyl acetate, hexane, mineral oil and non-polar solvents
- Stability: Hygroscopic, absorbs moisture rapidly in air; stable under neutral/weak acid conditions; prone to hydrolysis under strong alkaline heating; light stable under sealed low-temperature storage
Synthesis & Applications
Production Method
Soy lecithin phosphatidylcholine undergoes base-catalyzed transesterification, followed by desalting, decolorization, membrane separation and recrystallization purification to obtain L-α-GPC.
Main Applications
- Pharmaceutical API: Raw material for cognitive improvement drugs, used for senile dementia, memory decline, cerebrovascular dysfunction treatment
- Nootropic health food supplement: Choline nutritional supplement to boost learning, memory and brain focus; easily crosses blood-brain barrier to synthesize acetylcholine
- Sports nutrition raw material: Improves muscle strength, endurance and exercise recovery
- Biochemical research reagent: Phospholipid metabolism research substrate, raw material for artificial phospholipid synthesis
- Cosmetic additive: Skin cell nutrition ingredient, improves skin hydration and anti-aging
Safety & Storage Instructions
GHS Hazard Classification
Low-toxic substance, Warning signal word
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation from dust inhalation
- Oral LD50 in mice >13 g/kg, extremely low acute toxicity
Personal Protection
Dust mask, chemical splash goggles, nitrile gloves; operate in ventilated environment, avoid long-term dust contact
Storage Condition
Hermetically sealed moisture-proof aluminum foil bag/plastic drum, cool dark warehouse (≤20°C); isolate strong alkaline substances, strictly prevent moisture absorption
Transportation
General food/pharmaceutical raw material; sealed waterproof packaging, avoid high temperature and dampness
Quality Specifications
- Purity (anhydrous basis): 98.0%–102.0% (HPLC)
- Loss on Drying: ≤0.5% (powder grade)
- Residue on Ignition: ≤0.1%
- Heavy Metal (Pb): ≤10 ppm, Arsenic ≤2 ppm
- Choline content: ~40% of total mass
Information Summary Table
| Item | Specification |
| CAS Number | 28319-77-9 |
| Product Name | Choline glycerophosphate |
| Synonym | Alpha-GPC, L-α-Glycerylphosphorylcholine, Choline Alfoscerate |
| Molecular Formula | C8H20NO6P |
| Molecular Weight | 257.22 |
| Appearance | White hygroscopic powder / viscous liquid |
| Melting Point | 142.5–143°C |
| Solubility | Fully soluble in water and short-chain alcohols |
| Purity Standard | 98.0%–102.0% anhydrous |
| Storage Condition | Sealed moisture-proof cool dark storage, away from strong alkali |
| Hazard Property | Low toxicity, dust mildly irritates skin, eyes and respiratory tract |
| Main Usage | Cognitive pharmaceutical raw material, brain health nutritional supplement, sports nutrition additive, biochemical research reagent |
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