Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: N-Acetylneuraminic acid
CAS Number: 131-48-6
Alias: Neu5Ac, Sialic acid
Molecular Formula: C11H19NO9
Molecular Weight: 309.27
IUPAC Name: (2R,4R,5R,6R)-5-acetamido-2,4-dihydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)oxane-2-carboxylic acid
Structural Information
- Structure Type: Natural nine-carbon amino sugar (sialic acid), acidic monosaccharide derivative
- Structural Features: Pyranose six-membered ring skeleton, carries carboxyl group, N-acetylamino and multiple hydroxyl groups; negatively charged in aqueous solution, widely distributed on cell surface glycoproteins/glycolipids, participates cell recognition, virus adhesion
Physical & Chemical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slight sweet-sour taste
- Melting Point: 184–186 °C (decomposition)
- Specific Rotation: [α]D2? ?32° (c=1, water)
- Solubility: Freely soluble in water; slightly soluble in methanol; insoluble in ethanol, acetone, ether, alkanes
- Stability: Stable under weak acid and neutral cold storage; easily hydrolyzed at high temperature or strong acid to release N-acetyl group; decomposed under strong alkaline heating; light-stable when sealed, hygroscopic
Synthesis & Applications
Production Method
- Biological extraction: Isolation from egg yolk, bovine submaxillary gland
- Microbial fermentation: Fermentation culture of engineered bacteria for large-scale production
- Chemical total synthesis: Multi-step condensation of monosaccharide building blocks
Main Applications
- Biochemical research reagent: Standard substance for glycobiology, cell surface glycan analysis, virus infection mechanism research
- Health care raw material: Nutritional supplement for infant formula, supporting brain development and immunity regulation
- Pharmaceutical intermediate: Raw material for anti-influenza drug development (influenza neuraminidase inhibitor screening substrate)
- Medical diagnostic reagent: Marker for tumor and inflammatory disease detection
Safety & Storage Instructions
GHS Hazard Classification
Low-toxic compound, Warning signal word
- H315 Skin irritation by dust
- H319 Serious eye irritation
- H335 May irritate respiratory tract
Personal Protection
Dust mask, chemical goggles, nitrile gloves; operate under ventilation to avoid dust inhalation
Storage Condition
Hermetically sealed light-proof moisture-proof container, 2–8°C cool dry storage; isolate strong acid and strong alkali
Transportation
General biological raw material; avoid high temperature, sunlight and dampness
Quality Specifications
- Purity: ≥98.0% (HPLC)
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Heavy Metal (Pb): ≤10 ppm
Information Summary Table
| Item | Specification |
| CAS Number | 131-48-6 |
| Product Name | N-Acetylneuraminic acid |
| Synonym | Neu5Ac, Sialic acid |
| Molecular Formula | C11H19NO9 |
| Molecular Weight | 309.27 |
| Appearance | White crystalline powder |
| Melting Point | 184–186°C (decompose) |
| Solubility | Easily soluble in water, insoluble in non-polar solvents |
| Purity Standard | ≥98.0% |
| Storage Condition | Sealed light-proof low-temperature dry storage, away from strong acid/alkali |
| Hazard Property | Low toxicity, dust mild irritant to skin, eyes and respiratory tract |
| Main Usage | Glycobiology research reagent, infant nutritional additive, anti-influenza drug research substrate, medical diagnostic raw material |
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