Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Monobenzone
CAS Number: 103-16-2
Alias: 4-Benzyloxyphenol, Hydroquinone monobenzyl ether
Molecular Formula: C13H12O2
Molecular Weight: 200.23
IUPAC Name: 4-(benzyloxy)phenol
Structural Information
- Structure Type: Aromatic phenolic ether depigmenting agent
- Structural Features: Hydroquinone skeleton with one hydroxyl group and one benzyl ether substituent; inhibits melanocyte activity, irreversibly destroys melanin synthesis cells, strong skin whitening depigmentation effect
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Melting Point: 117–119 °C
- Solubility: Insoluble in water; soluble in ethanol, methanol, acetone, ether, benzene; slightly soluble in vegetable oil
- Stability: Stable under cool dark sealed storage; easily oxidized and discolored under strong light, high temperature and alkaline environment; reacts with oxidants to generate quinone impurities
Synthesis & Applications
Production Method
Hydroquinone reacts with benzyl chloride under alkaline catalysis, controlled single etherification, recrystallization purification.
Main Applications
- Pharmaceutical API: Vitiligo depigmentation treatment raw material, bleaching excessive residual pigment around vitiligo lesions
- Cosmetic raw material: Medical-grade strong whitening depigmenting ingredient (restricted use in cosmetic regulations)
- Organic synthesis intermediate: Antioxidant and polymerization inhibitor for polymer materials
Safety & Storage Instructions
GHS Hazard Classification
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
- Long-term skin contact may cause permanent skin depigmentation
Personal Protection
Dust mask, chemical splash goggles, nitrile gloves; operate in ventilated fume hood, avoid prolonged skin contact
Storage Condition
Hermetically sealed light-proof container, cool dry warehouse; isolate alkaline substances and oxidants
Transportation
General pharmaceutical solid raw material; avoid sunlight and dampness
Quality Specifications
- Purity: ≥99.0% (HPLC)
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Free hydroquinone impurity: ≤0.1%
Information Summary Table
| Item | Specification |
| CAS Number | 103-16-2 |
| Product Name | Monobenzone |
| Synonym | 4-Benzyloxyphenol, Hydroquinone monobenzyl ether |
| Molecular Formula | C13H12O2 |
| Molecular Weight | 200.23 |
| Appearance | White crystalline powder |
| Melting Point | 117–119°C |
| Solubility | Insoluble in water, soluble in alcohols and ketones |
| Purity Standard | ≥99.0% |
| Storage Condition | Sealed light-proof cool dry storage, away from alkali and oxidants |
| Hazard Property | Skin/eye/respiratory mild irritant, permanent depigmentation risk with long-term contact |
| Main Usage | Vitiligo medical depigmenting API, polymer antioxidant intermediate |
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