Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Cyclen
CAS Number: 294-90-6
Alias: 1,4,7,10-Tetraazacyclododecane
Chemical Full Name: 1,4,7,10-tetraazacyclododecane
Molecular Formula: C12H28N4
Molecular Weight: 200.38
EINECS: 206-030-1
Structural Information
- Structure Type: Macrocyclic tetraaza aliphatic ring chelating ligand
- Structural Features: Twelve-membered saturated heterocyclic ring containing four evenly spaced secondary amine nitrogen atoms; four N atoms provide multiple coordination sites, forms highly stable complexes with transition metal, rare earth and heavy metal ions
- Characteristic: Classic macrocyclic chelator, easily modified on nitrogen to generate functionalized derivatives (DOTA, DO3A etc.)
Physical & Chemical Properties
- Appearance: White crystalline solid
- Odor: Faint amine odor
- Melting Point: 110–113 °C
- Solubility: Freely soluble in water, methanol, ethanol; slightly soluble in chloroform; insoluble in alkanes, ethers
- Stability: Stable under dry sealed storage; alkaline substance, reacts with acids to form ammonium salts; undergoes alkylation, carboxylation on N atoms; susceptible to oxidation under high temperature and air exposure
Synthesis & Applications
Production Method
Cyclization reaction of bis(2-chloroethyl)amine hydrochloride and ethylenediamine under alkaline condition, followed by purification via recrystallization or distillation.
Main Applications
- Medical contrast agent intermediate: Precursor for DOTA/Gd-DOTA MRI gadolinium contrast media
- Metal ion chelating reagent: Separation and purification of rare earth metal ions
- Catalyst ligand: Macrocyclic ligand for transition metal coordination catalysts
- Heavy metal capture material: Raw material for wastewater heavy metal adsorbent resin
- Radiopharmaceutical carrier: Chelator for radioactive metal nuclides in targeted tumor therapy
Safety & Storage Instructions
GHS Hazard Classification
- H314 Causes severe skin burns and eye damage
- H335 May cause respiratory irritation from amine vapor/dust
Personal Protection
Full-face acid-resistant goggles, butyl nitrile impermeable gloves, alkali-resistant protective clothing, dust/mist respirator; operate in fume hood, avoid contact with skin and inhalation of vapors.
Storage Condition
Hermetically sealed nitrogen-filled plastic drum, cool dry ventilated warehouse ≤25℃; isolate acids, oxidants, carbon dioxide atmosphere.
Transportation
Corrosive organic alkaline solid; separate from acidic chemicals during transit, prevent container moisture ingress.
Quality Specifications
- Purity (HPLC/GC): ≥99.0%
- Loss on Drying: ≤0.2%
- Residue on Ignition: ≤0.1%
- Moisture content: ≤0.1%
Information Summary Table
| Item | Specification |
| CAS Number | 294-90-6 |
| Product Name | Cyclen |
| Synonym | 1,4,7,10-Tetraazacyclododecane |
| Molecular Formula | C12H28N4 |
| Molecular Weight | 200.38 |
| Appearance | White crystalline solid |
| Melting Point | 110–113℃ |
| Core Advantage | Tetraaza macrocycle, strong metal chelating capacity, key MRI contrast agent intermediate |
| Storage Rule | Sealed dry storage, isolate acid & CO? |
| Hazard Property | Strong alkaline corrosive, burns skin and eyes, irritates respiratory tract |
| Main Usage | MRI contrast agent intermediate, rare earth chelator, metal catalyst ligand, heavy metal wastewater treatment raw material |
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