Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: L-Hydroxyproline
CAS Number: 51-35-4
Alias: L-4-Hydroxyproline, (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
Chemical Full Name: (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid
Molecular Formula: C5H9NO3
Molecular Weight: 131.13
EINECS: 200-091-1
Structural Information
- Structure Type: Natural chiral cyclic amino acid, pyrrolidine derivative
- Structural Features: Five-membered pyrrolidine ring structure, contains carboxyl group, secondary amino group and hydroxyl group at C4 position; chiral carbon atoms, only L-type exists in animal collagen; hydroxyl group forms hydrogen bonds to stabilize collagen triple helix structure
- Characteristic: Special amino acid unique to collagen, easily soluble in water, weak acid property
Physical & Chemical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slight sweet taste
- Melting Point: 274–276 °C (decomposes)
- Specific Rotation: [α]D2? -76° ~ -79° (c=5, water)
- Solubility: Freely soluble in water; slightly soluble in ethanol; insoluble in acetone, ether, benzene
- Stability: Stable under dry sealed storage; resistant to mild heat and weak acid/alkali; will racemize under strong alkaline high temperature; participates in peptide condensation reaction to form collagen polypeptide
Synthesis & Applications
Production Method
Hydrolysis of animal skin/bone collagen, decolorization, ion exchange desalting, concentration and recrystallization purification; or microbial fermentation synthetic route.
Main Applications
- Pharmaceutical raw material: Collagen repair medicine, bone and joint health preparation, wound healing auxiliary drug
- Health food additive: Collagen nutrition supplement, anti-aging functional food raw material
- Cosmetic active ingredient: Skin moisturizing anti-aging additive, promotes collagen synthesis, improves skin elasticity
- Biochemical reagent: Standard substance for collagen content detection, cell culture medium nutrient
Safety & Storage Instructions
GHS Hazard Classification
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation from dust inhalation
Personal Protection
Dust mask, chemical splash goggles, nitrile gloves; operate in ventilated workshop to avoid long-term dust inhalation.
Storage Condition
Hermetically sealed light-proof plastic bag/drum, cool dry warehouse ≤25℃; isolate strong acid and strong alkaline substances, prevent moisture absorption.
Transportation
General food & pharmaceutical raw material solid; waterproof packaging to avoid caking.
Quality Specifications
- Purity (HPLC): ≥99.0%
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Heavy Metal (Pb): ≤10 ppm
Information Summary Table
| Item | Specification |
| CAS Number | 51-35-4 |
| Product Name | L-Hydroxyproline |
| Synonym | L-4-Hydroxyproline |
| Molecular Formula | C5H9NO3 |
| Molecular Weight | 131.13 |
| Appearance | White crystalline powder |
| Melting Point | 274–276℃ (decomposition) |
| Core Advantage | Collagen-specific chiral amino acid, promotes collagen regeneration |
| Storage Rule | Sealed cool dry storage, avoid damp and strong acid/alkali |
| Hazard Property | Low toxicity, dust mildly irritates skin, eyes and respiratory tract |
| Main Usage | Collagen health care raw material, cosmetic anti-aging additive, pharmaceutical intermediate, biochemical detection standard |
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