Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: 4-Hydroxyindole
CAS Number: 2380-94-1
Alias: 1H-Indol-4-ol
Chemical Full Name: 1H-indol-4-ol
Molecular Formula: C8H7NO
Molecular Weight: 133.15
EINECS: Not available
Structural Information
- Structure Type: Aromatic nitrogen-containing heterocyclic pharmaceutical intermediate
- Structural Features: Indole fused ring skeleton with hydroxyl group substituted at the 4-position of benzene ring; conjugated aromatic structure, easy to undergo electrophilic substitution reaction, can be used to synthesize a variety of indole-based targeted drugs
- Characteristic: Key building block for central nervous system drugs, chiral drug intermediates
Physical & Chemical Properties
- Appearance: Off-white to light pink crystalline powder
- Odor: Odorless
- Melting Point: 100–104 °C
- Solubility: Slightly soluble in water; soluble in methanol, ethanol, ethyl acetate, dichloromethane; insoluble in alkanes
- Stability: Stable under light-proof sealed low-temperature storage; easily oxidized and discolored when exposed to air and strong light; reacts with acid, alkali and acylating agents; phenolic hydroxyl group has weak acidity
Synthesis & Applications
Production Method
Multi-step cyclization synthesis using 2,3-dinitrophenol as starting material, followed by reduction, ring closure and recrystallization purification.
Main Applications
- Pharmaceutical Intermediate: Core raw material for antidepressants, serotonin receptor modulators, anti-migraine drugs
- Biochemical Reagent: Research raw material for neurotransmitter analogues
- Fine Chemical Intermediate: Precursor for indole fluorescent dyes
Safety & Storage Instructions
GHS Hazard Classification
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation from dust inhalation
Personal Protection
Dust respirator, chemical splash goggles, nitrile gloves; operate in ventilated fume hood, avoid long-term dust contact.
Storage Condition
Hermetically sealed light-proof plastic drum, cool dry warehouse ≤25℃; isolate oxidants, avoid sunlight exposure to prevent oxidation discoloration.
Transportation
General fine chemical solid powder; waterproof packaging to prevent dampness and oxidation.
Quality Specifications
- Purity (HPLC): ≥98.0%
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Single impurity: ≤0.1%
Information Summary Table
| Item | Specification |
| CAS Number | 2380-94-1 |
| Product Name | 4-Hydroxyindole |
| Synonym | 1H-Indol-4-ol |
| Molecular Formula | C8H7NO |
| Molecular Weight | 133.15 |
| Appearance | Off-white crystalline powder |
| Melting Point | 100–104℃ |
| Core Advantage | Indole heterocyclic skeleton, special pharmaceutical intermediate for CNS drugs |
| Storage Rule | Light-proof sealed low-temperature storage, away from oxidants |
| Hazard Property | Low toxicity, dust irritates skin, eyes and respiratory tract |
| Main Usage | Antidepressant drug intermediate, serotonin drug building block, biochemical research reagent |
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