Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: 4-Hydroxycoumarin
CAS Number: 1076-38-6
Alias: 4-Hydroxy-2H-chromen-2-one
Chemical Full Name: 4-hydroxy-2H-chromen-2-one
Molecular Formula: C9H6O3
Molecular Weight: 162.14
EINECS: 214-050-2
Structural Information
- Structure Type: Benzopyran heterocyclic pharmaceutical intermediate
- Structural Features: Coumarin fused ring with phenolic hydroxyl at C4 position; active enol hydroxyl group, easy to undergo condensation, alkylation, complexation reactions; core parent skeleton for anticoagulant rodenticides and anticoagulant medicines
- Characteristic: Key starting material for coumarin series anticoagulant derivatives
Physical & Chemical Properties
- Appearance: White to pale yellow crystalline powder
- Odor: Odorless
- Melting Point: 208–210 °C
- Solubility: Slightly soluble in cold water, soluble in hot water, methanol, ethanol, ethyl acetate, alkaline aqueous solution; insoluble in petroleum ether
- Stability: Stable under light-proof sealed storage; phenolic hydroxyl shows weak acidity, dissolves in alkali to form salt; easy to oxidize and turn dark under strong light; undergoes condensation reaction with aldehydes/ketones
Synthesis & Applications
Production Method
Condensation cyclization of methyl salicylate and ethyl acetate under strong alkaline catalysis, acid precipitation, recrystallization purification.
Main Applications
- Pharmaceutical Intermediate: Parent raw material for warfarin, dicoumarol and other oral anticoagulant drugs
- Rodenticide Intermediate: Synthetic precursor of coumarin anticoagulant rodenticides
- Fluorescent Dye Intermediate: Raw material for coumarin fluorescent whitening agents and laser dyes
- Analytical Reagent: Metal ion chelating fluorescent detection reagent
Safety & Storage Instructions
GHS Hazard Classification
- H302 Harmful if swallowed
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation from dust inhalation
Personal Protection
Dust respirator, full-face splash goggles, nitrile impermeable gloves; operate in fume hood, avoid accidental ingestion and long-term dust exposure.
Storage Condition
Hermetically sealed light-proof cardboard drum lined with PE film, cool dry warehouse ≤25℃; isolate oxidants, strong alkali, avoid sunlight oxidation discoloration.
Transportation
General toxic fine chemical solid; separate from food, feed during transit, prevent package breakage leakage.
Quality Specifications
- Purity (HPLC): ≥99.0%
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Single unknown impurity: ≤0.1%
Information Summary Table
| Item | Specification |
| CAS Number | 1076-38-6 |
| Product Name | 4-Hydroxycoumarin |
| Synonym | 4-Hydroxy-2H-chromen-2-one |
| Molecular Formula | C9H6O3 |
| Molecular Weight | 162.14 |
| Appearance | White crystalline powder |
| Melting Point | 208–210℃ |
| Core Advantage | Classic coumarin parent ring, anticoagulant drug & rodenticide core intermediate |
| Storage Rule | Light-proof sealed low-temperature storage, away from oxidants |
| Hazard Property | Harmful by oral intake, dust irritates skin, eyes and respiratory tract |
| Main Usage | Anticoagulant pharmaceutical intermediate, coumarin rodenticide raw material, fluorescent dye precursor |
...
Product
