Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Chloramphenicol
CAS Number: 56-75-7
Alias: Chloromycetin, 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Chemical Full Name: 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Molecular Formula: C11H12Cl2N2O5
Molecular Weight: 323.13
EINECS: 200-287-4
Structural Information
- Structure Type: Broad-spectrum chiral synthetic antibiotic
- Structural Features: Contains dichloroacetamide group, two chiral carbon atoms, p-nitrobenzene ring and two hydroxyl groups; inhibits bacterial protein synthesis, effective against Gram-positive and Gram-negative bacteria
- Characteristic: Classic broad-spectrum antibacterial raw material, widely used in human medicine, veterinary drugs and topical preparations
Physical & Chemical Properties
- Appearance: White to pale yellow crystalline powder
- Odor: Odorless, slightly bitter taste
- Melting Point: 149–153 °C
- Specific Rotation: [α]D2? +18.5° ~ +21.5° (ethanol solution)
- Solubility: Slightly soluble in water; freely soluble in ethanol, methanol, acetone, ethyl acetate; insoluble in benzene, petroleum ether
- Stability: Stable under light-proof sealed storage; decomposes and discolors under strong light; hydrolyzes under strong acid/alkali heating to lose antibacterial activity
Synthesis & Applications
Production Method
Multi-step chiral synthesis using nitrobenzaldehyde as starting material, condensation, reduction, dichloroacetylation, recrystallization purification.
Main Applications
- Pharmaceutical API: Raw material for chloramphenicol tablets, eye drops, ointments, broad-spectrum antibacterial treatment
- Veterinary Medicine Raw Material: Antibacterial additive for livestock, poultry and aquaculture
- Biochemical Reagent: Bacteriostatic agent for cell culture medium
- External Antiseptic Raw Material: Antibacterial ingredient for skin care anti-acne preparations
Safety & Storage Instructions
GHS Hazard Classification
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation from dust inhalation
- H341 Suspected of causing genetic defects
Personal Protection
Dust mask, full-face chemical splash goggles, nitrile impermeable gloves; operate in ventilated fume hood, avoid long-term dust exposure and skin absorption.
Storage Condition
Hermetically sealed light-proof cardboard drum lined with PE film, cool dry warehouse ≤25℃; isolate strong acid, alkali and oxidants, strictly avoid sunlight.
Transportation
Pharmaceutical raw material solid powder; separate from food and feed during transit, light-proof and moisture-proof packaging.
Quality Specifications
- Purity (HPLC): 98.0%–102.0%
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Heavy Metal (Pb): ≤10 ppm
Information Summary Table
| Item | Specification |
| CAS Number | 56-75-7 |
| Product Name | Chloramphenicol |
| Synonym | Chloromycetin |
| Molecular Formula | C11H12Cl2N2O5 |
| Molecular Weight | 323.13 |
| Appearance | White crystalline powder |
| Melting Point | 149–153℃ |
| Core Advantage | Broad-spectrum chiral antibiotic API, antibacterial for human & veterinary use |
| Storage Rule | Light-proof sealed dry storage, avoid strong light and acid/alkali |
| Hazard Property | Suspected genetic toxicity, dust irritates skin, eyes and respiratory tract |
| Main Usage | Human antibacterial medicine API, veterinary antibacterial raw material, cell culture bacteriostatic agent |
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