Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: CHRYSAROBIN CRUDE FROM GOA POWDER
CAS Number: 491-58-7
Alias: Crude Chrysarobin, Chrysophanol-9-anthrone, 1,8-Dihydroxy-3-methylanthrone, Goa Powder Extract
Chemical Full Name: 1,8-dihydroxy-3-methyl-10H-anthracen-9-one
Molecular Formula: C??H??O?
Molecular Weight: 240.25
EINECS: Not available
Structural Information
- Structure Type: Natural anthrone-type plant crude extract dermatological API raw material
- Structural Features: Anthracene fused ring skeleton with two phenolic hydroxyl groups and methyl substitution at C3; crude product extracted from Andira araroba wood (Goa powder), mixed with plant fiber, resin and chrysophanic acid impurities; phenolic anthrone structure has strong antifungal, anti-psoriasis pharmacological activity
- Characteristic: Natural crude dermatological raw material, traditional external medicine for psoriasis, tinea and chronic eczema
Physical & Chemical Properties
- Appearance: Brownish-orange to yellow-brown coarse crystalline powder (crude grade, darker than purified chrysarobin)
- Odor: Almost odorless, slight plant woody smell
- Melting Point: Pure monomer 203–204℃; crude batch wide melting range
- Solubility: Practically insoluble in water; slightly soluble in ethanol, ether; soluble in chloroform, benzene, hot vegetable oil, alkaline aqueous solution (turns bright red in alkali liquor)
- Stability: Oxidizes gradually under light and air to produce chrysophanic acid quinone, darkens color; stable under light-proof sealed storage; irritates skin and mucous membranes severely
Synthesis & Extraction Process
Production Method
Crude extract directly obtained from grinding & hot solvent extraction of Goa powder (araroba wood powder from Brazilian leguminous tree Andira araroba), simple filtration and drying without deep recrystallization, retains natural plant impurities.
Main Applications
- Dermatological raw material: External ointment raw material for psoriasis, ringworm, tinea versicolor, chronic eczema, lichen planus
- Antifungal pharmaceutical intermediate: Precursor for refined chrysarobin pharmaceutical grade after purification
- Veterinary external antibacterial agent: Skin fungal infection treatment for livestock
- Biochemical research reagent: Natural anthrone active monomer for dermatology pharmacology research
Safety & Storage Instructions
GHS Hazard Classification
- H302 Harmful if swallowed (oral absorption causes kidney damage, gastroenteritis)
- H314 Causes severe skin burns and eye damage
- H335 Irritates respiratory tract dust inhalation
- H317 May cause allergic skin reaction
Personal Protection
Dust respirator, full-face anti-chemical splash goggles, thick nitrile gloves, fully covered protective overalls; operate in fume hood, avoid large-area skin contact and eye splashing.
Storage Condition
Hermetically sealed light-proof PE lined cardboard drum, cool dry warehouse ≤25℃; isolate oxidants, strong alkaline substances, strictly avoid sunlight to prevent oxidation discoloration.
Transportation
Toxic fine chemical plant extract powder; separate from food, feed, drinking water sources during transit, moisture-proof & light-shield packaging.
Quality Specifications (Crude Goa Powder Grade)
- Active Chrysarobin content (HPLC): ≥80%–96% (commercial crude standard 90% min)
- Loss on Drying: ≤1.0%
- Total ash residue: ≤2.0%
- Plant fiber insoluble impurities: ≤5.0%
- Heavy metal (Pb): ≤20 ppm
Information Summary Table
| Item | Specification |
| CAS Number | 491-58-7 |
| Product Name | CHRYSAROBIN CRUDE FROM GOA POWDER |
| Synonym | Crude Chrysarobin, Chrysophanol-9-anthrone |
| Molecular Formula | C15H12O3 |
| Molecular Weight | 240.25 |
| Appearance | Brownish yellow crude crystalline powder |
| Core Advantage | Natural plant crude dermatological raw material, anti-psoriasis & broad-spectrum antifungal |
| Storage Rule | Light-proof sealed dry storage, away from alkali & oxidants |
| Hazard Property | Severe skin/mucous membrane irritant, harmful by ingestion, nephrotoxic risk via skin absorption |
| Main Usage | Psoriasis & tinea external ointment raw material, refined chrysarobin upstream crude extract, veterinary antifungal raw material |
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